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Adult Stem Cells

ZenBio, a pioneer in the adult stem cell field, delivers quality, cost-effective adipose-derived stem cells in large enough quantities to meet a wide range of project demands. Each lot is evaluated and qualified to remain undifferentiated in culture or to differentiate into osteoblasts, chondrocytes or adipocytes upon exposure to specific differentiation media formulations.

As interest grows in the expanding field of stem cell research, areas such as regenerative medicine, tissue engineering and basic stem cell biology necessitate a reliable cost-effective cell-based tool for use in discovery and design projects. Adipose-derived adult stem cells and their unique differentiation properties can be utilized in any number of research applications and offer decided benefits over similar multipotent cell types.

Adipose tissue is typically in greater supply enabling ample sourcing for isolation and production of adult stem cells – at a fraction of the cost for bone marrow-derived counterparts while maintaining similar markers and characteristics. Adult stem cells offer another more subtle benefit allowing scientists to circumvent the ethical issues normally associated with employing embryonic stem cells in biomedical research.

ZenBio adult stem cells are available with optimized media formulations to maximize growth, survival and differentiation in culture. All cells have been screened negative for HIV-1, HIV-2, HTLC-1, HTLV-2, Hep-B, Hep-C, and mycoplama.

2 week old Adult Stem Cells Figure 1 Adult stem cells differentiated into adipocytes. Cells shown are two weeks old and have been stained with the neutral lipid dye Oil Red O.
Differentiated Adult Stem Cells Figure 2 Adult stem cells differentiated into osteoblasts. Mineralized cells stained with Alizarin Red.
Differentiated Adult Stem Cell Figure 3 Adult stem cells differentiated into chondrocytes. Cells stained with Alcian Blue.

Ordering Information:

Adult Stem Cells

Item#Item DescU/MPrice
ASC-FCryopreserved Adipose derived Adult Stem Cells, 1 million cells/vialVial$234.00
ASC-F-SLCryopreserved Adipose derived Adult Stem Cells (POOLED), 1 million cells/vialVial$234.00
HBMMSC-FCryopreserved Human Bone Marrow derived Mesenchymal Stem Cells, 1 million cells/vialVial$650.00
BMSC-1Bone Marrow Stem Cell Growth Medium500ml$125.00
DM-2Adipocyte Differentiation Medium100ml$97.00
DM-2-500Adipocyte Differentiation Medium500ml$395.00
AM-1Adipocyte Maintenance Medium500ml$91.00
OB-1Osteoblast Differentiation Medium for Adipose Derived500ml$112.00
HBMOB-1Osteoblast Differentiation Media for Bone Barrow Mesenchymal Stem Cells 500ml500ml$112.00
CM-1-100Chondrocyte Differentiation Medium100ml$249.00
CM-1Chondrocyte Differentiation Medium500ml$1212.00
FM-1-100Cryopreservation Medium100ml$162.00

Contact Us For More Information

Human Adult Stem Cell Manual

A comprehensive list of products and prices can be found at Retail Prices (.PDF).

Recent Publications:View
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Impact of isolation method on doubling time and the quality of chondrocyte and osteoblast differentiated from murine dental pulp stem cells Rohaya Megat Abdul Wahab, Nur Akmal Mohamed Rozali , Sahidan Senafi, Intan Zarina Zainol Abidin, Zaidah Zainal Ariffin, Shahrul Hisham Zainal Ariffin
10.7717/peerj.3180
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Mechanical Properties and Cell Compatibility of Agarose Hydrogels Containing Proteoglycan Mimetic Graft Copolymers Hannah M. Pauly, Laura W. Place, Tammy L. Haut Donahue, and Matt J Kipper
DOI: 10.1021/acs.biomac.7b00643
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Persistence and proliferation of human mesenchymal stromal cells in the right ventricular myocardium after intracoronary injection in a large animal model of ... Roza Badr Eslam, Kevin Croce, Fernanda Marinho Mangione, Robert Musmann, Jane A. Leopold, Richard N. Mitchell, Aaron B. Waxman
http://doi.org/10.1016/j.jcyt.2017.03.002
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Human Adipose-Derived Stem Cells Labeled with Plasmonic Gold Nanostars for Cellular Tracking and Photothermal Cancer Cell Ablation Shammas, Ronnie L. B.S.; Fales, Andrew M. B.S.; Crawford, Bridget M. B.S.; Wisdom, Amy J. B.S.; Devi, Gayathri R. Ph.D.; Brown, David A. M.D., Ph.D.; Vo-Dinh, Tuan Ph.D.; Hollenbeck, Scott T. M.D.
doi: 10.1097/PRS.0000000000003187
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Osteoblast cellular activity on low elastic modulus Ti–24Nb–4Zr–8Sn alloy K.C. Nunea, R.D.K. Misraa, S.J. Lib, Y.L. Haob, R. Yangb
http://dx.doi.org/10.1016/j.dental.2016.11.005
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Functional response of osteoblasts in functionally gradient titanium alloy mesh arrays processed by 3D additive manufacturing K.C. Nunea, A. Kumara, R.D.K. Misraa, S.J. Lib, Y.L. Haob, R. Yang
http://dx.doi.org/10.1016/j.colsurfb.2016.09.050
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Ligand Independent and Subtype-Selective Actions of Thyroid Hormone Receptors in Human Adipose Derived Stem Cells Aleksandra Cvoro, Aleksandar Bajic, Aijun Zhang, Marisa Simon, Igor Golic, Douglas H. Sieglaff, Mirjana Maletic-Savatic, Aleksandra Korac, Paul Webb
Published: October 12, 2016 http://dx.doi.org/10.1371/journal.pone.0164407
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Screening ToxCast™ prioritized chemicals for PPARG function in a human adipose-derived stem cell model of adipogenesis Briana Foley, Daniel Doheny, Michael Black, Salil N. Pendse, Barbara Wetmore, Rebecca Clewell, Melvin E. Andersen, and Chad Deisenroth
Toxicol. Sci. (2016)doi: 10.1093/toxsci/kfw186
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Anatomically shaped tissue-engineered cartilage with tunable and inducible anticytokine delivery for biological joint resurfacing Franklin T. Moutosa, Katherine A. Glassb,c,d, Sarah A. Comptona, Alison K. Rossb,c, Charles A. Gersbachd, Farshid Guilaka, and Bradley T. Estes
doi: 10.1073/pnas.1601639113
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In situ characterization of the mTORC1 during adipogenesis of human adult stem cells on chip Xuanye Wua,b, Nils Schneidera,b, Alina Platena,b, Indranil Mitraa,b, Matthias Blazeka,b, Roland Zengerleb,c, Roland Schüleb,d,e, and Matthias Meier
doi: 10.1073/pnas.1601207113
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STEM CELL EPIGENETICS, GENOMICS, AND PROTEOMICS AXELLE LORIOT, a SVEN REISTER, a GREGORY K. PARVIZI, a PHILIPPE A. LYSY, b CHARLES DE SMET
STEM CELLS 2009;27:822–824
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Biological functionality and mechanistic contribution of extracellular matrix-ornamented three dimensional Ti-6Al-4V mesh scaffolds A. Kumar, K.C. Nune and R.D.K. Misra
DOI: 10.1002/jbm.a.35809
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The functional response of bioactive titania modified three‐dimensional Ti-6Al-4V mesh structure toward providing a favorable pathway for intercellular ... K.C. Nune, R.D.K. Misra, S.J. Li2, Y.L. Hao and W. Zhang
DOI: 10.1002/jbm.a.35789
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Mechanical Properties and Cellular Response of Novel Electrospun Nanofibers for Ligament Tissue Engineering: Effects of Orientation and Geometry Hannah M. Paulya, Daniel J. Kellyb, c, d, e, Ketul C. Popata, f, Nathan A. Trujillof, Nicholas J. Dunneg, h, Helen O. McCarthyi, Tammy L. Haut Donahue
doi:10.1016/j.jmbbm.2016.03.022
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Validation of Housekeeping Genes to Study Human Gingival Stem Cells and Their In Vitro Osteogenic Differentiation Using Real-Time RT-qPCR Ihsène Ta\hi, Ali Nassif, Tsouria Berbar, Juliane Isaac, Ariane Berdal, Bruno Gogly, and Benjamin Philippe Fournier
Stem Cells International Article ID 718046
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Interplay between Self-assembled Structure of Bone Morphogenetic Protein-2 (BMP-2) and Osteoblast Functions in Three-Dimensional Titanium Alloy Scaffolds: Stimulation of Osteogenic Activity K.C. Nune, A. Kumar, L.E. Murr and R.D.K. Misra
DOI: 10.1002/jbm.a.35592
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Detection of early stage changes associated with adipogenesis using Raman spectroscopy under aseptic conditions Adam Mitchell, Lorna Ashton, Xuebin B. Yang, Royston Goodacre, Alistair Smith and Jennifer Kirkham,
Article first published online: 6 OCT 2015
DOI: 10.1002/cyto.a.22777
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Validation of Housekeeping Genes to Study Human Gingival Stem Cells and Their in Vitro Osteogenic Differentiation Using Real-Time RT-qPCR. Ihséne Taïhi1, Ali Nassif, Tsouria Berbar, Juliane Isaac , Ariane Berdal1, Bruno Gogly, Benjamin Philippe Fournier
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Mesenchymal Stem Cell–Like Properties of Orbital Fibroblasts in Graves' OrbitopathyMesenchymal Stem Cells in Grave's Orbitopathy Katarzyna Kozdon; Caroline Fitchett; Geoffrey E. Rose; Daniel G. Ezra; Maryse Bailly
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 5743-5750. doi:10.1167/iovs.15-16580
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Characteristic expression of MSX1, MSX2, TBX2 and ENTPD1 in dental pulp cells Sakiko Fujii Katsumi Fujimoto Noriko Goto Masami Kanawa Takeshi Kawamoto Haiou Pan Petcharin Srivatanakul Waralak Rakdang Juthamas Pornprasitwech Tania Saskianti Ketut Suardita Fusanori Nishimura Yukio Kato
Biomedical Reports, 2015
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Fact versus artifact: Avoiding erroneous estimates of sulfated glycosaminoglycan content using the dimethylmethylene blue colorimetric assay for tissue-engineered ... C.H. Zheng and M.E. Levenston
European Cells and Materials Vol. 29 2015 (pages 224-236), ISSN 1473-2262
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3D hydrogel model using adipose-derived stem cells for vocal fold augmentation. H. Park, S. Karajanagi, K. Wolak, J. Aanestad, L. Deheron, J. Kobler, G. Lopez-Guerra, J. Heaton, R. S. Langer and S. Zeitels Tissue Eng Part A 2010; 16:535-543. download pdf
Impaired Activation of Protein Kinase C- by Insulin and Phosphatidylinositol-3,4,5-(PO4)3 in Cultured Preadipocyte-Derived Adipocytes and Myotubes of Obese Subjects. M. P. Sajan, M. L. Standaert, A. Miura, G. Bandyopadhyay, P. Vollenweider, D. M. Franklin, R. Lea-Currie, and R. V. Farese J. Clin. Endocrinol. Metab., Aug 2004; 89: 3994 - 3998. download pdf
Adipose-Derived Stem Cells for Regenerative Medicine. Jeffrey M. Gimble, Adam J. Katz, and Bruce A. Bunnell Circ. Res., May 2007; 100: 1249 - 1260. download pdf
MicroRNA-143 Regulates Adipocyte Differentiation. Christine Esau, Xiaolin Kang, Eigen Peralta, Elaine Hanson, Eric G. Marcusson, Lingamanaidu V. Ravichandran, Yingqing Sun, Seongjoon Koo, Ranjan J. Perera, Ravi Jain, Nicholas M. Dean, Susan M. Freier, C. Frank Bennett, Bridget Lollo, and Richard Griffey J. Biol. Chem., Dec 2004; 279: 52361 - 52365. download pdf
The ubiquitin ligase Fbxw7 controls adipocyte differentiation by targeting C/EBPα for degradation. Maria T. Bengoechea-Alonso and Johan Ericsson PNAS 2010 107 (26) 11817-11822; doi:10.1073/pnas.0913367107 download pdf
DNA methylation-associated repression of cancer-germline genes in human embryonic and adult stem cells A. Loriot, S. Reister, G. K. Parvizi, P. A. Lysy and C. De Smet Stem Cells. 2009; 27 (4): 822-4. download pdf
Adipose-derived Stem Cells as Therapeutic Delivery Vehicles of an Oncolytic Virus for Glioblastoma D. T. Josiah, D. Zhu, F. Dreher, J. Olson, G. McFadden and H. Caldas Mol Ther. 2009; Epub ahead of print download pdf
Functional properties of cell-seeded three-dimensionally woven poly(epsilon-caprolactone) scaffolds for cartilage tissue engineering F. Moutos and F. Guilak Tissue Eng Part A. 2009; Epub ahead of print download pdf
MicroRNA 132 regulates nutritional stress-induced chemokine production through repression of SirT1 J. C. Strum, J. H. Johnson, J. Ward, H. Xie, J. Feild, A. Hester, A. Alford and K. M. Waters Mol Endocrinol. 2009; 23 (11): 1876-84. download pdf
Stem Cells from Fat Bulge Their Way into Clinical Trials download pdf
Hydroxyapatite Reinforced Collagen Scaffolds with Improved Architecture and Mechanical Properties Robert J. Kane, Holly E. Weiss-Bilka, Matthew J. Meagher, Yongxing Liu, Joshua A. Gargac, Glen L. Niebur, Diane R. Wagner, Ryan K. Roeder download pdf
Development of a Human Adipose-Derived Stem Cell Model for Characterization of Chemical Modulation of Adipogenesis Foley Briana, Clewell Rebecca, and Deisenroth Chad. Applied In Vitro Toxicology download pdf

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