Metabolic disease is associated more closely with the accumulation of abdominal adipose in specific visceral depots. Recent studies have implicated omental and mesenteric adipose tissue in obesity-related insulin resistance, atherosclerosis, and type 2 diabetes. To provide the most relevant systems for investigating obesity-related morbidities, ZenBio is offering visceral derived human preadipocytes and cultured adipocytes to the research community.
Preadipocytes are isolated from omental, mesenteric, or perirenal adipose tissue and are tested for their ability to differentiate in culture to mature adipocytes. Preadipocytes are available cryopreserved or plated and mature adipocytes are available in a variety of plated formats.
Most cells are derived from obese non-diabetic patients (BMI>30), but there are limited quantities of preadipocytes and adipocytes from patients of BMI <27 as well as some lots of cells available from diabetic patients. Lots derived from multiple patients are also available as Pooled- or Super-lots.
There are limited quantities of donor matched omental and subcutaneous preadipocytes or cultured adipocytes for studies comparing the two depots.
The greater omentum is the largest peritoneal fold within the abdomen and has an immunologic function. The omentum aids in isolating peritoneal infection and absorbing contaminants through the mesothelial stomata. Adipokines and fatty acids from this depot have direct access to the liver through the portal circulation which may lead to hepatic dysfunction.
Mesenteric adipose lies within the thin layers of the peritoneal mesothelium connecting the small and large intestine. Adipose accumulation within this depot correlates with an increased risk of metabolic disease.
Perirenal adipose resides near the kidneys outside the peritoneal cavity. Fat from this depot has not been correlated with increased risk for metabolic disease.
Specially formulated media are available for use with our omental preadipocytes and adipocytes.
|OP-2006-3||Omental Preadipocytes 6-Well Plate, BMI >30.0||Each||$1,027.00|
|OP-2012-3||Omental Preadipocytes 12-Well Plate, BMI >30.0||Each||$831.00|
|OP-2024-3||Omental Preadipocytes 24-Well Plate, BMI >30.0||Each||$831.00|
|OP-2048-3||Omental Preadipocytes 48-Well Plate, BMI >30.0||Each||$831.00|
|OP-2096-3||Omental Preadipocytes 96-Well Plate, BMI >30.0||Each||$556.00|
|OP-F-1||Cryopreserved, Omental (1 million cells/vial), BMI <25.0||Vial||$428.00|
|OP-F-2||Cryopreserved, Omental (1 million cells/vial), BMI 25.0-29.9||Vial||$428.00|
|OP-F-3||Cryopreserved, Omental (1 million cells/vial), BMI >30.0||Vial||$428.00|
|OP-F-SL||Cryopreserved, Omental (1 million cells/vial), (POOLED Donor Lot)||Vial||$428.00|
|OPD-F||Cryopreserved, Omental (1 million cells/vial), DIABETIC||Vial||$641.00|
|OPD-F-3||Cryopreserved, Omental Preadipocytes, DIABETIC (1 million cells/vial), BMI >30.0||Vial||$641.00|
|OPD-F-SL||Cryopreserved, Omental (1 million cells/vial), DIABETIC, (POOLED Donor Lot)||Vial||$641.00|
|OA-1006-3||Omental Adipocytes 6-Well Plate, BMI >30.0||Each||$1,170.00|
|OA-1012-3||Omental Adipocytes 12-Well Plate, BMI >30.0||Each||$975.00|
|OA-1024-3||Omental Adipocytes 24-Well Plate, BMI >30.0||Each||$975.00|
|OA-1048-3||Omental Adipocytes 48-Well Plate, BMI >30.0||Each||$975.00|
|OA-1096-3||Omental Adipocytes 96-Well Plate, BMI >30.0||Each||$669.00|
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A comprehensive list of products and prices can be found at Retail Prices(.PDF).
Renewable Source of Human Beige Adipocytes for Development of Therapies to Treat Metabolic SyndromeSu Su, Anyonya R.Guntur, Daniel C. Nguyen, Shameem S. Fakory, Chad C. Doucette, Cassandra Leech, Humphrey Lotana, Matthew Kelley, Jaspreet Kohli, Julieta Martino, Sunder Sims-Lucas, Lucy Liaw, Calvin Vary, Clifford J. Rosen, Aaron C. Brown
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Effects of exosomes from LPS-activated macrophages on adipocyte gene expression, differentiation, and insulin-dependent glucose uptakeDe Silva, N., Samblas, M., MartÃnez, J.A. et al. J Physiol Biochem (2018).
Resistin exposure of human omental adipocytes affects transcriptional regulation processes involved in cellular differentiation and maintenance.Sotiriou, Alexandros
University. Promotor(en): Ivonne Rietjens, co-promotor(en): Jacques Vervoort. - Wageningen : Wageningen University - ISBN 9789463430302 - 137 p
Hydroxytyrosol, an ingredient of olive oil, reduces triglyceride accumulation and promotes lipolysis in human primary visceral adipocytes during differentiationBruno Stefanon, Monica Colitti
Exp Biol Med (Maywood) June 10, 2016 1535370216654226
Chemokine profiles of human visceral adipocytes from cryopreserved preadipocytes: Neutrophil activation and induction of nuclear factor-kappa B repressing factorRui Yamaguchia, b, Takatoshi Yamamotoa, Arisa Sakamotoa, Yasuji Ishimarua, Shinji Naraharaa, Hiroyuki Sugiuchia, Yasuo Yamaguchi
Published: July 1, 2015DOI: 10.1371/journal.pone.0132105
Molecules 2015, 20, 8409-8428; doi:10.3390/molecules20058409
Journal of Metabolic Syndrome, March 2015