Mouse 3T3-L1 Cell Line Systems
ZenBio now offers Cryopreserved and Cultured 3T3-L1 Preadipocytes!
3T3-L1 murine adipocytes have been fundamental in metabolic disease research for over 30 years. Originally derived from Swiss mouse embryo tissue by Dr. Howard Green of Harvard Medical School, the 3T3-L1 system has been pivotal in advancing the understanding of basic cellular mechanisms associated with diabetes, obesity and related disorders.
We now offer both Cryopreserved and Plated sub-confluent 3T3-L1 preadipocytes in 96 well format and media for proliferation, differentiation, maintenance of 3T3-L1 preadipocytes to adipocytes. We also offer media and reagent kits validated using 3T3-L1 and/or primary rodent preadipocytes and adipocytes. High quality control tested 3T3-L1 preadipocytes designed to work consistently using ZenBio's line of 3T3-L1 media.
"We have just conducted an experiment with the 3T3L1 cells that we obtained from ZenBio, and we are astounded by the results! In our previous experience with 3T3L1 cells obtained from ATCC and Sigma-Aldrich, it has always been a challenge to get a high percentage of the cells to differentiate into mature adipocytes...we obtained strong differentiation of virtually 100% of the cells to adipocytes on the first try!"– Vala Sciences, Inc
Cryopreserved & Cultured 3T3-L1 Preadipocytes
| Item# | Item Desc | U/M | Price |
|---|---|---|---|
| SP-L1-F | 3T3-L1 Preadipocytes Cryopreserved, (500,000 cells/vial) | Vial | $413.00 |
| SP-L1-96 | 3T3-L1 Preadipocytes 96-well Plate | Each | $447.00 |
| SP-L1-24 | 3T3-L1 Preadipocytes 24-well Plate | Plate | $447.00 |
| SP-L1-48 | 3T3-L1 Preadipocytes 48-well Plate | Each | $447.00 |
| SP-L1-T25 | 3T3-L1 Cultured Preadipocytes, T-25cm2 Flask | Flask | $636.00 |
Media
| Item# | Item Desc | U/M | Price |
|---|---|---|---|
| AM-1-L1 | 3T3-L1 Adipocyte Medium | 500ml | $136.00 |
| AM-1-L1-PRF | 3T3-L1 Adipocyte Medium Phenol Red Free | 500ml | $155.00 |
| AM-1-L1-IF | 3T3-L1 Adipocyte Medium WITHOUT Insulin | 500ml | $155.00 |
| AM-1-L1-DF | 3T3-L1 Adipocyte Medium WITHOUT Dexamethasone | 500ml | $155.00 |
| AM-1-L1-SF | 3T3-L1 Adipocyte Medium WITHOUT Serum | 500ml | $155.00 |
| AM-1-L1-ABF | 3T3-L1 Adipocyte Medium WITHOUT ANTIBIOTICS | 500ml | $145.00 |
| DM-2-L1 | 3T3-L1 Differentiation Medium | 100ml | $145.00 |
| DM-2-L1-500 | 3T3-L1 Differentiation Medium | 500ml | $626.00 |
| DM-2-L1-PRF | 3T3-L1 Differentiation Medium, WITHOUT Phenol Red | 100ml | $159.00 |
| DM-2-L1-500-PRF | 3T3-L1 Differentiation Medium, WITHOUT Phenol Red | 500ml | $626.00 |
| DM-2-L1-ABF | 3T3-L1 Differentiation Medium, WITHOUT ANTIBIOTICS | 500ml | $626.00 |
| DM-2-L1-PPG | 3T3-L1 Differentiation Medium WITHOUT PPAR gamma agonist | 100ml | $155.00 |
| PM-1-L1 | 3T3-L1 Preadipocyte Medium | 500ml | $136.00 |
| PM-1-L1-PRF | 3T3-L1 Preadipocyte Medium Phenol Red Free | 500ml | $155.00 |
| PM-1-L1-ABF | 3T3-L1 Preadipocyte Medium, WITHOUT ANTIBIOTICS | 500ml | $155.00 |
| PM-1-L1-SF | 3T3-L1 Preadipocyte Medium, WITHOUT SERUM | 500ml | $125.00 |
| BM-1-L1 | 3T3-L1 Basal Medium | 500ml | $125.00 |
| FM-1-L1 | Cryopreservation Medium for 3T3-L1 cells | 100ml | $242.00 |
Kits
| Item# | Item Desc | U/M | Price |
|---|---|---|---|
| LIP-1-L1 | Lipolysis Assay Kit for 3T3-L1 cells, Glycerol Detection-100 point, (REAGENTS+ CELLS) | Kit | $889.00 |
| LIP-1-L1-F | Lipolysis Assay Kit for 3T3-L1 cells, Glycerol Detection-100 point, WITH CRYOPRESERVED CELLS(REAGENTS+ CELLS) | Kit | $818.00 |
| LIP-1-NCL1 | Lipolysis Assay Kit for 3T3-L1 cells, Glycerol Detection-100 point, (REAGENTS ONLY) | Kit | $463.00 |
| LIP-1-NCL1DIF | Lipolysis Assay Kit for 3T3-L1 cells, Glycerol Detection, WITH 3T3-L1 Media to differentiate 1 X 96 well plate (REAGENTS+ MEDIA) | Kit | $611.00 |
| KT-01 | 3T3-L1 Preadiopcyte Differentiation Kit Reagents sufficient to differentiate and maintain 1x96 well plate of 3T3-L1 Cells | Kit | $153.00 |
| KT-01-PRF | 3T3-L1 Preadipocyte Differentiation Kit: Reagents sufficient to differentiate and maintain 1x96 well plate of 3T3-L1 Cells (PHENOL RED- FREE) | Kit | $169.00 |
| LIP-2-NC-L1 | 3T3-L1 Lipolysis Assay Kit, Free Fatty Acid+ Detection,100 point assay kit (REAGENTS ONLY) | Kit | $591.00 |
| LIP-2-L1 | 3T3-L1 Lipolysis Assay Kit, Free Fatty Acid Detection (REAGENTS+ CELLS) | Kit | $1015.00 |
| LIP-3-NC-L1 | 3T3-L1 Lipolysis Assay KIT (REAGENTS ONLY) Combo-Free Fatty acid and glycerol release | Kit | $837.00 |
| LIP-3-L1 | 3T3-L1 Lipolysis Kit- Dual Detection Free Fatty Acid and Glycerol Release 100 point assay kit,+ (REAGENTS CELLS) | Kit | $1185.00 |
Contact Us For More Information
3T3-L1 Adipocyte Care Manual (.PDF)
A comprehensive list of products and prices can be found at Retail Prices (.PDF).
3T3-L1 Publications
Sex-specific genetic regulation of adipose mitochondria and metabolic syndrome by Ndufv2
Karthickeyan Chella Krishnan, Laurent Vergnes, Rebeca Acín-Pérez, Linsey Stiles, Michael Shum, Lijiang Ma, Etienne Mouisel, Calvin Pan, Timothy M. Moore, Miklós Péterfy, Casey E. Romanoski, Karen Reue, Johan L. M. Björkegren, Markku Laakso, Marc Liesa & Aldons J. LusisDOI https://doi.org/10.1038/s42255-021-00481-w
The middle lipin domain adopts a membrane-binding dimeric protein fold
Weijing Gu, Shujuan Gao, Huan Wang, Kaelin D. Fleming, Reece M. Hoffmann, Jong Won Yang, Nimi M. Patel, Yong Mi Choi, John E. Burke, Karen Reue & Michael V. AirolaDOI: https://doi.org/10.1038/s41467-021-24929-5
Linoleic acid exerts antidiabetic effects by inhibiting protein tyrosine phosphatases associated with insulin resistance
Sun-Young Yoon, Dohee Ahn, Young Hwang, Min Ji Kang, Sang J.Chunghttps://doi.org/10.1016/j.jff.2021.104532
Tumor-derived IL-6 and trans-signaling among tumor, fat, and muscle mediate pancreatic cancer cachexia
Joseph E. Rupert, Ashok Narasimhan, Daenique H.A. Jengelley, Yanlin Jiang, Jianguo Liu , Ernie Au, Libbie M. Silverman, George Sandusky, Andrea Bonetto, Sha Cao, Xiaoyu Lu, Thomas M. O'Connell, Yunlong Liu, Leonidas G. Koniaris, Teresa A. ZimmersJ Exp Med (2021) 218 (6): e20190450. https://doi.org/10.1084/jem.20190450
SIRT1 promotes lipid metabolism and mitochondrial biogenesis in adipocytes and coordinates adipogenesis by targeting key enzymatic pathways
Yasser Majeed, Najeeb Halabi, Aisha Y. Madani, Rudolf Engelke, Aditya M. Bhagwat, Houari Abdesselem, Maha V. Agha, Muneera Vakayil, Raphael Courjaret, Neha Goswami, Hisham Ben Hamidane, Mohamed A. Elrayess, Arash Rafii, Johannes Graumann, Frank Schmidt & Nayef A. MazloumDOIhttps://doi.org/10.1038/s41598-021-87759-x
Epigenetic effects induced by the ectopic expression of Pax7 in 3T3-L1
Alaa Elgaabari, Atsuko Miyawaki-Kuwakado, Kosuke Tomimatsu, Qianmei Wu, Kosuke Tokunaga, Wakana Izumi, Takahiro Suzuki, Ryuichi Tatsumi, Mako NakamurThe Journal of Biochemistry, mvab030, https://doi.org/10.1093/jb/mvab030
Signal Transducer and Activator of Transcription 3 (STAT3) Suppresses STAT1/Interferon Signaling Pathway and Inflammation in Senescent Preadipocytes
Aisha Y. Madani, Yasser Majeed, Houari B. Abdesselem, Maha V. Agha, Muneera Vakayil, Nour K. Al Sukhun, Najeeb M. Halabi, Pankaj Kumar, Shahina Hayat, Mohamed A. Elrayess, Arash Rafii, Karsten Suhre and Nayef A. MazloumAntioxidants 2021, 10, 334. https://doi.org/10.3390/antiox10020334
GRIM19 Impedes Obesity by Regulating Inflammatory White Fat Browning and Promoting Th17/Treg Balance. Cells 2021, 10, 162
JooYeon Jhun, Jin Seok Woo, Seung Hoon Lee, Jeong-Hee Jeong, KyungAh Jung, Wonhee Hur, Seon-Yeong Lee, Jae Yoon Ryu, Young-Mee Moon, Yoon Ju Jung, Kyo Young Song, Kiyuk Chang, Seung Kew Yoon, Sung-Hwan Park and Mi-La ChoDOI:10.3390/cells10010162
Characterization of adipogenic, PPARγγ, and TRβ activities in house dust extracts and their associations with organic contaminants
Christopher D. Kassotis, Kate Hoffman, Allison L. Phillips, Sharon Zhang, Ellen M. Cooper, Thomas F. Webster, Heather M. Stapletonhttps://doi.org/10.1016/j.scitotenv.2020.143707
Adipocytes from SERCA2 knockout mice exhibit a dysregulation in the secretion of adiponectin and resistin
Divya BansalMaster Degree Project, University of Skövde
The bile acid induced hepatokine orosomucoid suppresses adipocyte differentiation
Sung Ho Lee, Jong Min Choi, Sung Yun Jung, Aaron R. Cox, Sean M. Hartig, David D. Moore, Kang Ho Kimhttps://doi.org/10.1016/j.bbrc.2020.10.086
Brain-derived neurotrophic factor modulates mitochondrial dynamics and thermogenic phenotype on 3T3-L1 adipocytes
M. Colitti and T. Montanarihttps://doi.org/10.1016/j.tice.2020.101388
HOXB13 controls cell state through super-enhancers
Paul-Joseph Aspuria, Dong-Joo Cheon, Maricel C. Gozo, Jessica A. Beach, Maria Sol Recouvreux, Ann E. Walts, Beth Y. Karlan, Sandra Orsulichttps://doi.org/10.1016/j.yexcr.2020.112039
14-3-3ζ regulates lipolysis by influencing adipocyte maturity
Abel Oppong, Kadidia Diallo, Isabelle Robillard Frayne, Christine Des Rosiers, Gareth E. Limdoi: https://doi.org/10.1101/2020.02.24.962662
Reducing 14-3-3ζ expression influences adipocyte maturity and impairs function
Abel K. Oppong, Kadidia Diallo, Isabelle Robillard Frayne, Christine Des Rosiers, Gareth E. LimDOI: 10.1101/2020.02.24.962662
Betatrophin knockdown induces beiging and mitochondria biogenesis of white adipocytes
Zhe-Zhen Liao, Xiao-Yan Qi, Yadi Wang, Jiao-Yang Li, Qian-Qian Gu, Can Hu, Yin Hu, Heng Sun, Li Ran, Jing Yang, Jiang Hua Liu and Xinhua XiaoDOI: https://doi.org/10.1530/JOE-19-0447
Intermittent Hypoxia Stimulates Lipolysis, But Inhibits Differentiation and De Novo Lipogenesis in 3T3-L1 Cells
Martina Musutova, Martin Weiszenstein, Michal Koc, and Jan Polakhttps://doi.org/10.1089/met.2019.0112
Abundant Active Ingredients of Green Tea Regulate Glucose Metabolism in 3T3-L1 Cell Line
AL-Shaeli Sattar, Ethaeb Ali, Brown JamesDOI : 10.5958/0973-9130.2019.00381.5
Journal of Nutritional Biology Insulin Receptor Levels Regulated by the Receptor-Associated Protein Progesterone Receptor Membrane Component 1 (PGRMC1)
Hampton KK and Craven RJJ Nutri Bio, 4(2): 189-195 (2018)
m6A methylation modulates adipogenesis through JAK2-STAT3-C/EBPβ signaling
Ruifan Wu, Guanqun Guo, Zhen Bi, Youhua Liu, Yuanling Zhao, Nana Chen, Fengqin Wang, Yizhen Wang, Xinxia Wanghttps://doi.org/10.1016/j.bbagrm.2019.06.008
Quizalofop-p-ethyl induces adipogenesis in 3T3-L1 adipocytes
Martina Biserni, Robin Mesnage, Raquel Ferro, Eva Wozniak, Theodoros Xenakis, Charles A Mein, and Michael N AntoniouToxicological Sciences, kfz097, https://doi.org/10.1093/toxsci/kfz097
A Lipophilic Fucoxanthin-Rich Phaeodactylum tricornutum Extract Ameliorates Effects of Diet-Induced Obesity in C57BL/6J Mice
Andrea Gille, Bojan Stojnic, Felix Derwenskus, Andreas Trautmann, Ulrike Schmid-Staiger, Clemens Posten, Karlis Briviba, Andreu Palou, M. Luisa Bonet and Joan RibotNutrients 2019, 11(4), 796; doi:10.3390/nu11040796
Thyroid receptor antagonism as a contributory mechanism for adipogenesis induced by environmental mixtures in 3T3-L1 cells
Christopher D.Kassotis, Erin M. Kollitz, Kate Hoffman, Julie Ann Sosa, Heather M. Stapletonhttps://doi.org/10.1016/j.scitotenv.2019.02.273
Guggulsterone Activates Adipocyte Beiging through Direct Effects on 3T3-L1 Adipocytes and Indirect Effects Mediated through RAW264. 7 Macrophages
Colette N. Miller, Janaiya S. Samuels, Yusra Azhar, Ashish Parmar, Rangaiah Shashidharamurthy, and Srujana RayalamMedicines 2019, 6, 22; doi:10.3390/medicines6010022
A comparison of methods for effective differentiation of the frozen-thawed 3T3-L1 cells
Xueyan Zhaoa, Hongmei Hua, Cheng Wang, Liya Bai, Yanping Wang, Weiwei Wang, Jiying Wanghttps://doi.org/10.1016/j.ab.2018.12.020
Antioxidant treatment induces reductive stress associated with mitochondrial dysfunction in adipocytes
Eduard Peris, Peter Micallef, Alexandra Paul, Vilborg Palsdottir, Annika Enejder, Marco Bauzá-Thorbrügge, Charlotta S. Olofsson and Ingrid Wernstedt Asterholmhttp://www.jbc.org/cgi/doi/10.1074/jbc.RA118.004253
Carbon monoxide-induced metabolic switch in adipocytes improves insulin resistance in obese mice
Laura Braud,1,2 Maria Pini,2,3 Lucie Muchova,4 Sylvie Manin,1,2 Hiroaki Kitagishi,5 Daigo Sawaki,2,3 Gabor Czibik,2,3 Julien Ternacle,2,3 Genevieve Derumeaux,2,3 Roberta Foresti,1,2 and Roberto Motterlini1,2JCI Insight. 2018;3(22):e123485. https://doi.org/10.1172/jci.insight.123485.
Regulation of obesity-associated metabolic disturbance by the antipsychotic drug olanzapine: Role of the autophagy-lysosome pathway
Xueli Zhang, Yi Zhao, Yamin Liu, Yang Yuan, Hua Shao, Xiao Zhenghttps://doi.org/10.1016/j.bcp.2018.10.001
8-(3-phenylpropyl)-1, 3, 7-triethylxanthine is a synthetic caffeine substitute with stronger metabolic modulator activity
David F.Carrageta, Tánia R.Dias, Ivana Jarak, cMarco G.Alves, Pedro F.Oliveira, Mietha M.Van der Walt, Gisella Terre'Blanche,Mariana P.Monteiro, Branca M.Silvahttps://doi.org/10.1016/j.tiv.2018.08.002
Evaluation of neonicotinoid insecticides for oestrogenic, thyroidogenic and adipogenic activity reveals imidacloprid causes lipid accumulation
Robin Mesnage, Martina Biserni, Dilyana Genkova, Ludovic Wesolowski, Michael N. AntoniouDOI: 10.1002/jat.3651
Paired box 7 inhibits differentiation in 3T3-L1 preadipocytes
Wakana Izumi, Yuko Takuma, Ryo Ebihara, Wataru Mizunoya, Ryuichi Tatsumi, Mako Nakamurahttps://doi.org/10.1111/asj.13050
Lanthionine synthetase C-like protein 2 (LanCL2) is Important for Adipogenic Differentiation
Debapriya Dutta, Kuan-Yu Lai, Adriana Reyes-Ordo&numl;ez, Jie Chen and Wilfred A. van der DonkJournal of Lipid Research
PCYT1A Regulates Phosphatidylcholine Homeostasis from the Inner Nuclear Membrane in Response to Membrane Stored Curvature Elastic Stress
Afreen Haider, Yu-Chen Wei, Koini Lim, Antonio D. Barbosa, Che-Hsiung Liu, Ursula Weber, Marek Mlodzik, Kadri Oras, Simon Collier, M. Mahmood Hussain, Liang Dong, Satish Patel, Anna Alvarez-Guaita, Vladimir Saudek, Benjamin J. Jenkins, Albert Koulman, Marcus K. Dymond, Roger C. Hardie, David B. Savagehttps://doi.org/10.1016/j.devcel.2018.04.012
Evaluation of anti-insulin receptor antibodies as potential novel therapies for human insulin receptoropathy using cell culture models
Gemma V. Brierley & Kenneth Siddle & Robert K. SempleDOI https://doi.org/10.1007/s00125-018-4606-2
Fusion of fibroblast growth factor 21 to a thermally responsive biopolymer forms an injectable depot with sustained anti-diabetic action
Caslin A. Gilroy, Stefan Roberts, Ashutosh Chilkotihttps://doi.org/10.1016/j.jconrel.2018.03.015
Transcriptional Regulation of TCF/LEF and PPAR γ by Daidzein and Genistein in 3T3-L1 Preadipocytes
Jeremy E. Davis and Darcie Hastingshttps://doi.org/10.1089/jmf.2017.0136
Xinxia Wang, Baofa Sun, Qin Jiang, Ruifan Wu, Min Cai, Yongxi Yao, Qing Liu, Hailing Shi, Jie Feng & Yizhen Wang
International Journal of Obesity (2018), doi:10.1038/s41366-018-0027-zIn vitro anti-diabetic effect of flavonoids and pheophytins from Allophylus cominia Sw. on the glucose uptake assays by HepG2, L6, 3T3-L1 and fat accumulation in 3T3 ...
D.G. Semaana, J.O. Igolia, c, L. Younga, A.I. Graya, E.G. Rowana, E. Marrerobhttps://doi.org/10.1016/j.jep.2018.01.014
The high-production volume fungicide pyraclostrobin induces triglyceride accumulation associated with mitochondrial dysfunction, and promotes adipocyte ...
Anthony L. Luz, Christopher D. Kassotis, Heather M. Stapleton, Joel N. Meyerhttps://doi.org/10.1016/j.tox.2017.11.010
Nonionic Ethoxylated Surfactants Induce Adipogenesis in 3T3-L1 Cells
Christopher D Kassotis Erin M Kollitz P Lee Ferguson Heather M Stapletonhttps://doi.org/10.1093/toxsci/kfx234
Interleukin-15 derived from Guanylin-GC-C-expressing macrophages inhibits fatty acid synthase in adipocytes
Sayaka Akieda-Asaia, Takanori Idaa, Mikiya Miyazatob, Kenji Kangawab, Yukari Datea https://doi.org/10.1016/j.peptides.2017.10.012Mesoderm specific transcript localization in the ER and ER-lipid droplet interface supports a role in adipocyte hypertrophy
Igor Prudovsky, Rea P. Anunciado-Koza, Chester G. Jacobs, Doreen Kacer, Matthew E. Siviski, Robert A. KozaDOI: 10.1002/jcb.26429
Retinol saturase modulates lipid metabolism and the production of reactive oxygen species
Xiao-YanPang, SuyaWang, Michael J.Jurczak, Gerald I.Shulman, Alexander R.Moisehttps://doi.org/10.1016/j.abb.2017.09.009
Dibutyltin Compounds Effects on PPARγ/RXRα Activity, Adipogenesis, and Inflammation in Mammalians Cells
Flora A. Milton, Mariella G. Lacerda, Simone B. P. Sinoti, Pedro G. Mesquita, Dileesh Prakasan, Michella S. Coelho, Caroline L. de Lima, Alexandre G. Martini, Gabriela T. Pazzine, Maria de F. Borin, Angelica A. Amato and Francisco de A. R. NevesFront. Pharmacol., 02 August 2017 https://doi.org/10.3389/fphar.2017.00507
Ciliary Hedgehog Signaling Restricts Injury-Induced Adipogenesis
Daniel Kopinke, Elle C. Roberson, Jeremy F. ReiterDOI: http://dx.doi.org/10.1016/j.cell.2017.06.035
Characterization of Adipogenic Activity of House Dust Extracts and Semi-Volatile Indoor Contaminants in 3T3-L1 Cells
Christopher D. Kassotis, Kate Hoffman, and Heather M. StapletonEnviron. Sci. Technol., Article ASAP
DOI: 10.1021/acs.est.7b01788
Total control of fat cells from adipogenesis to apoptosis using a xanthene analog
Ching-Hsuan Tung, Myung Shin Han, Jianjun QiPLoS ONE 12(6): e0179158. https://doi.org/10.1371/journal. pone.0179158
Phosphorylation of TXNIP by AKT Mediates Acute Influx of Glucose in Response to Insulin
Althea N. Waldhart, Holly Dykstra, Anderson S. Peck, Elissa A. Boguslawski, Zachary B. Madaj, Jennifer Wen, Kelsey Veldkamp, Matthew Hollowell, Bin Zheng, Lewis C. Cantley, Timothy E. McGraw, Ning Wuhttps://doi.org/10.1016/j.celrep.2017.05.041
Leucine-nicotinic acid synergy stimulates AMPK/Sirt1 signaling and regulates lipid metabolism and lifespan in Caenorhabditis elegans, and hyperlipidemia and ...
Antje Bruckbauer, Jheelam Banerjee, Quiang Cao, Xin Cui, Jia Jing, Lin Zha, Fenfen Li, Bingzhong Xue, Hang Shi, and Michael B ZemelAm J Cardiovasc Dis. 2017; 7(2): 33-47.
A biomimetic hydrogel functionalized with adipose ECM components as a microenvironment for the 3D culture of human and murine adipocytes
Fiona Louis, Pauline Pannetier, Zied Souguir, Didier Le Cerf, Philippe Valet, Jean-Pierre Vannier, Guillaume Vidal, Elise DemangeDOI: 10.1002/bit.26306
Novel role for Wnt inhibitor APCDD1 in adipocyte differentiation: implications for diet-induced obesity
Nicole K.H. Yiew, Tapan K. Chatterjee, Yao Liang Tang, Rod Pellenberg, Brian K. Stansfield, Zsolt Bagi, David J. Fulton, David W. Stepp, Weiqin Chen, Vijay Patel, Vinayak M. Kamath, Sheldon E. Litwin, David Y Hui, Steven M. Rudich, Ha Won Kim and Neal L. Weintraubdoi: 10.1074/jbc.M116.758078
IL-17 axis accelerates the inflammatory progression of obese in mice via TBK1 and IKBKE pathway
Seung Hoon Leea, JooYeon Jhuna, Jae-Kyung Byuna, Eun-Kyung Kima, KyoungAh Jungb, Ji Eun Leec, Jong Young Choid, Sung-Hwan Parka, Mi-La Choa,http://dx.doi.org/10.1016/j.imlet.2017.02.004
Parkinâ€mediated mitophagy is downregulated in browning of white adipose tissue
David Taylor, Roberta A. GottliebDOI: 10.1002/oby.21786
FAK signalling controls insulin sensitivity through regulation of adipocyte survival
Cynthia T. Luk, Sally Yu Shi, Erica P. Cai, Tharini Sivasubramaniyam, Mansa Krishnamurthy, Jara J. Brunt, Stephanie A. Schroer, Daniel A. Winer & Minna WooNat. Commun. 8,14360 doi: 10.1038/ncomms14360 (2017).
Characterization of Adipogenic Chemicals in Three Different Cell Culture Systems: Implications for Reproducibility Based on Cell Source and Handling
Christopher D. Kassotis, Lauren Masse, Stephanie Kim, Jennifer J. Schlezinger, Thomas F. Webster & Heather M. StapletonScientific Reports 7, Article number: 42104 (2017)
doi:10.1038/srep42104
Abscisic acid enhances glucose disposal and induces brown fat activity in adipocytes in vitro and in vivo
Laura Sturlaa, Elena Manninoa, Sonia Scarfìb, Santina Bruzzonea, Mirko Magnonea, Giovanna Socialia, Valeria Booza, Lucrezia Guidaa, Tiziana Vigliaroloa, Chiara Fresiaa, Laura Emionitec, Ambra Buschiazzod, Cecilia Marinie, f, Gianmario Sambucetid, f, Antonio De Floraa, Elena Zocchihttp://dx.doi.org/10.1016/j.bbalip.2016.11.005
Insulin resistance uncoupled from dyslipidemia due to C-terminal PIK3R1 mutations
Isabel Huang-Doran, Patsy Tomlinson, Felicity Payne, Alexandra Gast, Alison Sleigh, William Bottomley,Julie Harris, Allan Daly, Nuno Rocha, Simon Rudge, Jonathan Clark, Albert Kwok, Stefano Romeo, Emma McCann, Barbara Müksch, Mehul Dattani, Stefano Zucchini, Michael Wakelam, Lazaros C. Foukas, David B. Savage, Rinki Murphy, Stephen O'Rahilly, Inês Barroso, and Robert K. SempleJCI Insight. 2016 Oct 20; 1(17): e88766.
Soshiho-tang aqueous extract exerts antiobesity effects in high fat diet-fed mice and inhibits adipogenesis in 3T3-L1 adipocytes
Sae-Rom Yoo, Mee-young Lee, Byoung-Kab Kang, Hyeun-Kyoo Shin, Soo-Jin JeongKorea Institute of Oriental Medicine
White Adipocyte Adiponectin Exocytosis is Stimulated Via β3 Adrenergic Signaling and Activation of Epac1: Catecholamine Resistance in Obesity and Type 2...
Ali M. Komai, Saliha Musovic, Eduard Peris, Ahmed Alrifaiy, Mickaël F. El Hachmane, Marcus Johansson,Ingrid Wernstedt Asterholm, Charlotta S. OlofssonDiabetes 2016 Aug; db151597.http://dx.doi.org/10.2337/db15-1597
Adipogenesis, lipogenesis and lipolysis is stimulated by mild but not severe hypoxia in 3T3-L1 cells
Martin Weiszensteina, Martina Musutovaa, Andrea Plihalovaa, Katerina Westlakea, c, Moustafa Elkalafb, Michal Kocd, Antonin Prochazkae, Jan Palad, Sumeet Gulatia, Jan Trnkab, Jan Polakdoi:10.1016/j.bbrc.2016.08.015
HMGB1 is secreted by 3T3-L1 adipocytes through JNK signaling and the secretion is partially inhibited by adiponectin
Toshiaki Shimizu, Munekazu Yamakuchi, Kamal Krishna Biswas, Bibek Aryal, Shingo Yamada, Teruto Hashiguchi and Ikuro MaruyamaDOI: 10.1002/oby.21549
Antidiabetic Potential of Purple and Red Rice (Oryza sativa L.) Bran Extracts
Stephen M. Boue, Kim W. Daigle, Ming-Hsuan Chen, Heping Cao, and Mark L. HeimanJ. Agric. Food Chem., DOI: 10.1021/acs.jafc.6b01909
Ginger oil-mediated down-regulation of adipocyte specific genes inhibits adipogenesis and induces apoptosis in 3T3-L1 adipocytes
Thamilvaani Manaharan and M. S. KanthimathiBiochemistry and Biotechnology Research Vol. 4(2), pp. 38-47, May 2016 ISSN: 2354-2136
The commonly used nonionic surfactant Span 80 has RXRα transactivation activity, which likely increases the obesogenic potential of oil dispersants and food ...
Robert R. Bowersa, Alexis M. Temkinb, Louis J. Guilletteb, c, John E. Baatzc, d, Demetri D. Spyropoulosdoi:10.1016/j.ygcen.2016.04.029
The Effect of Pericellular Oxygen Levels on Proteomic Profile and Lipogenesis in 3T3-L1 Differentiated Preadipocytes Cultured on Gas-Permeable Cultureware
Martin Weiszenstein, Nela Pavlikova, Moustafa Elkalaf, Petr Halada, Ondrej Seda, Jan Trnka, Jan Kovar, Jan PolakPublished: March 29, 2016 http://dx.doi.org/10.1371/journal.pone.0152382
Ahnak stimulates BMP2â€mediated adipocyte differentiation through Smad1 activation
Sunmee Shin, Je Kyung Seong, and Yun Soo BaeDOI: 10.1002/oby.21367
Curcumin analogues as selective fluorescence imaging probes for brown adipose tissue and monitoring browning
Xueli Zhang, Yanli Tian, Hongbin Zhang, Amol Kavishwar, Matthew Lynes, Anna-Liisa Brownell, Hongbin Sun, Yu-Hua Tseng, Anna Moore & Chongzhao RanScientific Reports 5, Article number: 13116 (2015), doi:10.1038/srep13116
Role of Micro RNA-205 in Promoting Visceral Adiposity of NZ10 Mice with Polygenic Susceptibility for Type 2 Diabetes
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Traditional Korean herbal formula Samsoeum attenuates adipogenesis by regulating the phosphorylation of ERK1/2 in 3T3-L1 cells
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Hydroxytyrosol Inhibits Cannabinoid CB1 Receptor Gene Expression in 3T3-L1 Preadipocyte Cell Line
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PPARγ partial agonist GQ-16 strongly represses a subset of genes in 3T3-L1 adipocytes
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Traditional medicine yanggyuksanhwa-tang inhibits adipogenesis and suppresses proliferator-activated receptor gamma expression in 3T3-L1 cells
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Effects of Crude Oil/Dispersant Mixture and Dispersant Components on PPARγ Activity in Vitro and in Vivo: Identification of Dioctyl Sodium Sulfosuccinate (DOSS; CAS #577-11-7) as a Probable Obesogen
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Translocator protein (18kDa) as a pharmacological target in adipocytes to regulate glucose homeostasis
J Li, V Papadopoulos - Biochemical Pharmacology, 2015Adipocyte Secreted Factors Enhance Aggressiveness of Prostate Carcinoma Cells
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Leucine Amplifies the Effects of Metformin on Insulin Sensitivity and Glycemic Control in Diet-Induced Obese Mice
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EPAS1 Promotes Adipose Differentiation in 3T3-L1 Cells.
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