Human Cells
ZenBio was founded on the premise that researchers have more important work at hand that struggling with procuring tissue and isolating cells. Since our founding in 1995 we have established a robust tissue procurement network and world class cell isolation technologies in order to simplify research that requires primary cell systems. Our tissue collection and cell isolation procedures are all IRB approved and we have a rigorous quality control system that helps insure only the highest quality cells and media are shipped to our customers.
We have multiple cell systems currently in development so if you do not see a cell system that meets your needs, let us know and we will work to accommodate your request.
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Human Mononuclear Cells (MNCs) Publications
Single-Tube qPCR Detection and Quantitation of Hotspot Mutations Down to 0.01% Variant Allele Fraction
Kerou Zhang, Luis Rodriguez, Lauren Yuxuan Cheng, Michael Wang, and David Yu ZhangAnalytical Chemistry Article ASAP, DOI: 10.1021/acs.analchem.1c03716
Residues T48 and A49 in HIV-1 NL4-3 Nef are responsible for the counteraction of autophagy initiation, which prevents the ubiquitin-dependent degradation of Gag
Sergio Castro-Gonzalez, Yuexuan Chen, Jared Benjamin, Yuhang Shi & Ruth Serra-MorenoDOI https://doi.org/10.1186/s12977-021-00576-y
A highly-specific fully-human antibody and CAR-T cells targeting CD66e/CEACAM5 are cytotoxic for CD66e-expressing cancer cells in vitro and in vivo
Du-San Baek, Ye-Jin Kim, Sandra Vergara, Alex Conard, Cynthia Adams, Guillermo Calero RiekoIshima, John W. Mellors, Dimiter S.Dimitrovhttps://doi.org/10.1016/j.canlet.2021.10.041
LMWF5A Demonstrates an Anti-Inflammatory Mode of Action and Similar Drug Targets to Dexamethasone in Activated PBMC
Elizabeth D. Frederick, Melissa A. Hausburg, Gregory W. Thomas, David Bar-OrDOI: https://doi.org/10.21203/rs.3.rs-790987/v1
A Novel FACS-Based Workflow for Simultaneous Assessment of RedOx Status, Cellular Phenotype, and Mitochondrial Genome Stability. BioChem 2021, 1, 1-18
Patrick M. McTernan, Paige S. Katz, Constance Porretta, David A. Welsh and Robert W. SigginsBioChem 2021, 1(1), 1-18; https://doi.org/10.3390/biochem1010001
Direct in vivo reprogramming with non-viral sequential targeting nanoparticles promotes cardiac regeneration
Hae Min Yang, Bora Yim, Byung-Hyun Lee, Yongdoo Park, Young Gyu Kim, Jongseong Kim, and Dongwon Yoohttps://doi.org/10.1021/acsami.1c04827
The peptidoglycan-associated protein NapA plays an important role in the envelope integrity and in the pathogenesis of the lyme disease spirochete
Marisela M. Davis, Aaron M. Brock, Tanner G. DeHart, Brittany P. Boribong, Katherine Lee, Mecaila E. McClune, Yunjie Chang, Nicholas Cramer, Jun Liu, Caroline N. Jones, Brandon L. Jutrashttps://doi.org/10.1371/journal.ppat.1009546
Discovery of a novel RORγ antagonist with skin-restricted exposure for topical treatment of mild to moderate psoriasisSuxing Liu, Dong Liu, Ru Shen, Di Li, Qiyue Hu, Yinfa Yan, Jiakang Sun, Fengqi Zhang, Hong Wan, Ping Dong, Jun Feng, Rumin Zhang, Jing Li, Lianshan Zhang & Weikang Tao
DOI: https://doi.org/10.1038/s41598-021-88492-1
Targeting transforming growth factor-β2 by antisense oligodeoxynucleotide accelerates T cell-mediated tumor rejection in a humanized mouse model of triple
Hong Kyu Lee, Hyeong-Jin Ji, Sang-Kyung Shin, Jihye Koo, Tae Hun Kim, Cho-Won Kim, Yeon Hee Seong, Jun-Eui Park, Kyung-Chul ChoiDOI: 10.21203/rs.3.rs-363729/v1
Human adenylate kinase 6 regulates WNK1 (with no lysine kinase-1) phosphorylation states and affects ion homeostasis in NT2 cells
Seil Jang, Jaeho Song, Na Young Kim, Jeonghyeon Bak, Keehoon Jung, Young Woo Park, Bum-Chan Park, Ho MinKimhttps://doi.org/10.1016/j.biomaterials.2021.120760
ZBTB2 represses HIV-1 transcription and is regulated by HIV-1 Vpr and cellular DNA damage responses
James W. Bruce, Megan Bracken, Edward Evans, Nathan Sherer, Paul Ahlquisthttps://doi.org/10.1371/journal.ppat.1009364
In Vivo Quantitative Analysis of Anterior Chamber White Blood Cell Mixture Composition Using Spectroscopic Optical Coherence Tomography
RUOBING QIAN, RYAN P. MCNABB, KEVIN C. ZHOU, HAZEM M. MOUSA, DANIEL R. SABAN, VICTOR L. PEREZ, ANTHONY N. KUO, AND JOSEPH A. IZATTPBRM1 and the glycosylphosphatidylinositol biosynthetic pathway promote tumor killing mediated by MHC--unrestricted cytotoxic lymphocytes
Bridget L. Menasche, Eric M. Davis, Shifeng Wang, Yan Ouyang, Suzhao Li, Haijia Yu, Jingshi ShenMenasche et al., Sci. Adv. 2020; 6 : eabc3243 27 November 2020
Inhibition of Caspases Improves Non-Viral T Cell Receptor Editing
Chunxi Wang, Chun-Chi Chang, Liangli Wang and Fan YuanCancers 2020, 12, 2603; doi:10.3390/cancers12092603
Redirecting Vesicular Transport to Improve Nonviral Delivery of Molecular Cargo
Mao Mao, Chun-Chi Chang, Adrian Pickar-Oliver, Lisa D. Cervia, Liangli Wang, Jing Ji, Paloma B. Liton, Charles A. Gersbach, Fan Yuanhttps://doi.org/10.1002/adbi.202000059
TRIM28/TIF1β and Fli-1 negatively regulate peroxynitrite generation via DUOX2 to decrease the shedding of membrane-bound fractalkine in human macrophages
Rui Yamaguchi, Misa Haraguchi, Reona Yamaguchi, Arisa Sakamoto, Shinji Narahara, Hiroyuki Sugiuchi, Yasuo Yamaguchihttps://doi.org/10.1016/j.cyto.2020.155180
Highly efficient 'hit-and-run'genome editing with unconcentrated lentivectors carrying Vpr. Prot. Cas9 protein produced from RRE-containing transcripts
Ivana Indikova, Stanislav IndikNucleic Acids Research, gkaa561, https://doi.org/10.1093/nar/gkaa561
Biomimetic Tolerogenic Artificial Antigen Presenting Cells for Regulatory T Cell Induction
Kelly R. Rhodes, Randall A. Meyer, Justin Wang, Stephany Y. Tzeng, Jordan J. Green,https://doi.org/10.1016/j.actbio.2020.06.004
HIV and opiates dysregulate K+-Cl-cotransporter 2 (KCC2) to cause GABAergic dysfunction in primary human neurons and Tat-transgenic mice
Aaron J. Barbour, Kurt F. Hauser, Rory McQuiston, Pamela E. Knapphttps://doi.org/10.1016/j.nbd.2020.104878
Oncolytic measles virus therapy enhances tumor antigen-specific T-cell responses in patients with multiple myeloma
Nandakumar Packiriswamy, Deepak Upreti, Yumei Zhou, Rehan Khan, Amber Miller, Rosa M. Diaz, Cliona M. Rooney, Angela Dispenzieri, Kah-Whye Peng & Stephen J. RussellDOI: https://www.doi.org/10.1038/s41375-020-0828-7
Biomarkers of Genome Instability in Normal Mammalian Genomes Following Drug-induced Replication Stress
Sheroy Minocherhomji, Yang Liu, Yudong D. He, Mark R. Fieldenhttps://www.doi.org/10.1002/em.22364
Suppression of monosodium urate crystal-induced inflammation by inhibiting TGF-β-activated kinase 1-dependent signaling: role of the ubiquitin proteasome system
Anil K. Singh, Mahamudul Haque, Kayla O'Sullivan, Mukesh Chourasia, Madhu M. Ouseph & Salahuddin AhmedDOI: https://www.doi.org/10.1038/s41423-019-0284-3
Suppression of monosodium urate crystal-induced inflammation by inhibiting TGF-β-activated kinase 1-dependent signaling: role of the ubiquitin proteasome system
Anil K. Singh, Mahamudul Haque, Kayla O'Sullivan, Mukesh Chourasia, Madhu M. Ouseph & Salahuddin AhmedDOI: https://www.doi.org/10.1038/s41423-019-0284-3
A flexible high content imaging assay for profiling macrophage efferocytosis
Roger Clark, Laura Usselmann, Martin R.Brown, Anne U.Goeppert, Adam Corriganhttps://www.doi.org/10.1016/j.jim.2019.112636
Cricket paralysis virus internal ribosome entry site-derived RNA promotes conventional vaccine efficacy by enhancing a balanced Th1/Th2 response
Hye Won Kwak, Hyo-Jung Park, Hae Li Ko, Hyelim Park, Min Ho Cha, Sang-Myeong Lee, Kyung Won Kang, Rhoon-Ho Kim, Seung Rok Ryu, Hye-Jung Kim, Jae-Ouk Kim, Manki Song, Hun Kim, Dae Gwin Jeong, Eui-Cheol Shin, Jae-Hwan Namhttps://www.doi.org/10.1016/j.vaccine.2019.07.070
Experimental and Modeling Framework for the Production of Cell and Protein-Based Biopharmaceutical Products
Scibona, Ernesto, Doctoral Thesishttps://www.research-collection.ethz.ch/handle/20.500.11850/351146
Ribonucleoprotein: A Biomimetic Platform for Targeted siRNA Delivery
Wanyi Tai, Xiaohu Gaohttps://www.doi.org/10.1002/adfm.201902221
Ocular anterior chamber blood cell population differentiation using spectroscopic optical coherence tomography
RUOBING QIAN, WEI-FENG HUANG, RYAN P. MCNABB, KEVIN C. ZHOU, QING H. LIU, ANTHONY N. KUO, JOSEPH A. IZATThttps://www.doi.org/10.1364/BOE.10.003281
Management of all three phases of wound healing through the induction of fluorescence biomodulation using fluorescence light energy
Giovanni Scapagnini, Andrea Marchegiani, Giacomo Rossi, Michela Zago, Joanna Jowarska, Mohamed Wael, Shannon E. Campbell, Zachary Schiffman, Emanuela Buonamici, Ricardo Garvao, Remigio Piergallini, Matteo Cerquetella, Alessandro Fruganti, Fabrizio Dini, Fulvio Laus, Andrea SpaternaProceedings Volume 10863, Photonic Diagnosis and Treatment of Infections and Inflammatory Diseases II; 108630W (2019) https://www.doi.org/10.1117/12.2508066
Di-(2-ethylhexyl) phthalate, a peroxisome proliferator-activated receptor α agonist, promotes release of tissue factor-bearing microparticles from human M1 macrophages via the TGFβ1/Smad/PAI-1 signaling pathway
Rui Yamaguchi, Arisa Sakamoto, Reona Yamaguchi, Misa Haraguchi, Shinji Narahara, Hiroyuki Sugiuchi, Takahiko Katoh, YasuoYamaguchihttps://www.doi.org/10.1016/j.amjms.2019.02.012
Long noncoding RNA Malat1 regulates differential activation of macrophage and response to lung injury
Huachun Cui1, Sami Banerjee, Sijia Guo, Na Xie, Jing Ge1, Dingyuan Jiang, Martin Zörnig, Victor J Thannickal, Gang LiuJCI Insight. https://www.doi.org/10.1172/jci.insight.124522
Borrelia burgdorferi peptidoglycan is a persistent antigen in patients with Lyme arthritis
Brandon L. Jutras, Robert B. Lochhead, Zachary A. Kloos, Jacob Biboy, Klemen Strle, Joe Gray, Carmen J. Booth, Sander K. Govers, Waldemar Vollmer, Linda K. Bockenstedt, Allen C. Steere, Christine Jacobs-Wagnerhttps://www.doi.org/10.1016/j.vaccine.2011.10.073
Administration of Lactobacillus paracasei strains improves immunomodulation and changes the composition of gut microbiota leading to improvement of colitis in mice
Woon-Ki Kim, You Jin Jang, Boram Seo, Dae Hee Han, Sung Jun Park, Gwang Pyo Ko https://www.doi.org/10.1016/j.jff.2018.11.035RNA-Based Immunostimulatory Liposomal Spherical Nucleic Acids as Potent TLR7/8 Modulators
Chenxia Guan, Natalia Chernyak, Donye Dominguez, Lisa Cole, Bin Zhang, Chad A. Mirkinhttps://www.doi.org/10.1002/smll.201803284
Soluble Siglec-14 glycan-recognition protein is generated by alternative splicing and suppresses myeloid inflammatory responses
Po-Chun Jimmy Huang, Penk-Yeir Low, Iren Wang, Shang-Te Danny Hsu, and Takashi Angatadoi: 10.1074/jbc.RA118.005676
Migratory, Metabolic and Functional Alterations of Fibrocytes in Type 2 Diabetes
Audrey Walker, Erwin Nissen, Adolf Geigerhttps://www.doi.org/10.1002/iub.1920
Utilization of recombinant albumins in the expansion of human T lymphocytes
Atherly Pennybaker and Randall AlfanoDOI: 10.18609/cgti.2018.024
Genetic Variant Q63R of Cannabinoid Receptor 2 (CB2R) Causes Differential ERK Phosphorylation in Human Immune Cells
Wang Jingru, Xu Juehua, Liu Jie, Zhu Huang, Peng Yanyan, Ding Zhi-Ming, and Hua Haiqinghttps://www.doi.org/10.1089/gtmb.2018.0005
Multi-omics analysis reveals neoantigen-independent immune cell infiltration in copy-number driven cancers
Daniel J. McGrail, Lorenzo Federico, Yongsheng Li, Hui Dai, Yiling Lu, Gordon B. Mills, Song Yi, Shiaw-Yih Lin & Nidhi Sahnidoi:10.1038/s41467-018-03730-x
Functional Studies of Missense TREM2 Mutations in Human Stem Cell-Derived Microglia
Philip W. Brownjohn, James Smith, Ravi Solanki, Ebba Lohmann, Henry Houlden, John Hardy, Sabine Dietmann, and Frederick J. LiveseyDOI: https://www.doi.org/10.1016/j.stemcr.2018.03.003
Transcription factor specificity protein 1 modulates TGFβ1/Smad signaling to negatively regulate SIGIRR expression by human M1 macrophages stimulated with ...
Rui Yamaguchia, Arisa Sakamotoa, Reona Yamaguchib, Misa Haraguchia, Shinji Naraharaa, Hiroyuki Sugiuchia, Yasuo Yamaguchiahttps://www.doi.org/10.1016/j.cyto.2018.03.011
Development and Evaluation of Tri-Functional Immunoliposomes for the Treatment of HER2 Positive Breast Cancer
Vaidya, T., Straubinger, R.M. & Ait-Oudhia, S. Pharm Res (2018) 35: 95.https://www.doi.org/10.1007/s11095-018-2365-x
Regenerative potential of tonsil mesenchymal stem cells on surgical cutaneous defect
Sung-Chan Shin, Yoojin Seo, Hee Young Park, Da-Woon Jung, Tae-Hoon Shin, Haejin Son, Young Keum Kim, Jin-Choon Lee, Eui-Suk Sung, Jeon Yeob Jang, Hyung-Sik Kim & Byung-Joo LeeCell Death & Diseasevolume 9, Article number: 183 (2018), doi:10.1038/s41419-017-0248-4
Inhibitory Effects of Toll-Like Receptor 4, NLRP3 Inflammasome, and Interleukin-1β on White Adipocyte Browning
Meshail Okla, Walid Zaher, Musaad Alfayez, Soonkyu ChungDOI: https://www.doi.org/10.1007/s1075
Mediator Kinase Phosphorylation of STAT1 S727 Promotes Growth of Neoplasms With JAK-STAT Activation
Ioana I. Nitulescu, Sara C. Meyer, Qiang Jeremy Wen, John D. Crispino, Madeleine E. Lemieux, Ross L. Levine, Henry E. Pelish, Matthew D. ShairDOI: http://dx.doi.org/10.1016/j.ebiom.2017.11.013
Differential regulation of IL-23 production in M1 macrophages by TIR8/SIGIRR through TLR4-or TLR7/8-mediated signaling
RuiYamaguchi, ArisaSakamoto, TakatoshiYamamoto, ShinjiNarahara, YasuoYamaguchihttps://www.doi.org/10.1016/j.cyto.2017.08.014
Preclinical trial of the multi-targeted lenvatinib in combination with cellular immunotherapy for treatment of renal cell carcinoma
Chengkuan Cai Jingyuan Tang Baixin Shen Liucheng Ding Yunpeng Shao Zhengsen Chen Yinchao Ma Haoliang Xue Zhongqing Weihttps://www.doi.org/10.3892/etm.2017.4858
Activated macrophages control human adipocyte mitochondrial bioenergetics via secreted factors
Michaela Keuper, Stephan Sachs, Ellen Walheim, Lucia Berti, Bernhard Raedle, Daniel Tews, Pamela Fischer-Posovszky, Martin Wabitsch, Martin Hrabe de Angelis, Gabi Kastenmüller, Matthias H. Tschöp, Martin Jastroch, Harald Staiger, Susanna M. Hofmannhttp://dx.doi.org/10.1016/j.molmet.2017.07.008
Di-(2-ethylhexyl) phthalate suppresses IL-12p40 production by GM-CSF-dependent macrophages via the PPARα/TNFAIP3/TRAF6 axis after lipopolysaccharide ...
R Yamaguchi, A Sakamoto, T Yamamoto, S Narahara, H Sugiuchi, A Hisada, T Katoh, Y YamaguchiDOI: a href="https://www.doi.org/10.1177/0960327117714038" target="_blank">https://www.doi.org/10.1177/0960327117714038
Supplementary Information for High-throughput screening of rare metabolically active tumor cells in pleural effusion and peripheral blood of lung cancer patients
Yin Tanga, Zhuo Wanga, Ziming Lib, Jungwoo Kimc,d, Yuliang Denga, Yan Lie, James R. Heath, Wei Weic, Shun Lub,Qihui ShiaEvaluation of the Potency, Neutralizing Antibody Response, and Stability of a Recombinant Fusion Protein Vaccine for Streptococcus pyogenes
E. BurletH. HogenEschA. DunhamG. MorefieldDOI: 10.1208/s12248-017-0069-5
Activation of E-prostanoid 3 receptor in macrophages facilitates cardiac healing after myocardial infarction
Juan Tang, Yujun Shen, Guilin Chen, Qiangyou Wan, Kai Wang, Jian Zhang, Jing Qin, Guizhu Liu, Shengkai Zuo, Bo Tao, Yu Yu, Junwen Wang, Michael Lazarus & Ying Yudoi:10.1038/ncomms14656
BCA2/RABRING7 Interferes with HIV-1 Proviral Transcription by Enhancing the SUMOylation of IκBα
Marta Colomer-Llucha and Ruth Serra-MorenoJ. Virol. doi:10.1128/JVI.02098-16
Targeting IRE1 with Small Molecules Counteracts Progression of Atherosclerosis
Ozlem Tufanlia,, Pelin Telkoparan Akillilara, Diego Acosta-Alvearc, Begum Kocaturka, Umut I. Onata, Syed M. Hamida,, Ismail Cimena, Peter Walter, Christian Weberd,, Ebru ErbayMatrix Stiffness Exerts Biphasic Control Over Monocyte-Endothelial Adhesion via Rho-mediated ICAM-1 Clustering
Harry A Scott, Boi Quach, Xiao Yang, Soroush Ardekani, Andrea Paulina Cabrera, Randall Wilson, Ilhem Messaoudi-Power and Kaustabh GhoshIntegr. Biol., 2016, Accepted Manuscript
DOI: 10.1039/C6IB00084C
Lentivirus pre-packed with Cas9 protein for safer gene editing
J G Choi, Y Dang, S Abraham, H Ma, J Zhang, H Guo, Y Cai, J G Mikkelsen, H Wu, P Shankar and N ManjunathGene Therapy, (7 April 2016) | doi:10.1038/gt.2016.27
Neutrophil elastase enhances IL-12p40 production by lipopolysaccharide-stimulated macrophages via transactivation of the PAR-2/EGFR/TLR4 signaling pathway
Rui Yamaguchia, b, Takatoshi Yamamotoa, Arisa Sakamotoa, Shinji Naraharaa, Hiroyuki Sugiuchia, Yasuo Yamaguchidoi:10.1016/j.bcmd.2016.03.006
Inactivation of the miR-183/96/182 Cluster Decreases the Severity of Pseudomonas aeruginosa-Induced KeratitismiR-183/96/182 in P. aeruginosa-Induced Keratitis/a>
Chithra K. Muraleedharan; Sharon A. McClellan; Ronald P. Barrett; Cui Li; Daniel Montenegro; Thomas Carion; Elizabeth Berger; Linda D. Hazlett; Shunbin XuInvestigative Ophthalmology & Visual Science April 2016, Vol.57, 1506-1517. doi:10.1167/iovs.16-19134
Macrophage PPAR-γ and Impaired Wound Healing in Type 2 Diabetes
Rita E. Mirza, Milie M. Fang, Margaret L. Novak, Norifumi Urao, Audrey Sui, William J. Ennis andTimothy J. KohJournal of Pathology, DOI: 10.1002/path.4548
Repositioning Potential of PAK4 to Osteoclastic Bone Resorption†
Sik-Won Choi1,‡, Jeong-Tae Yeon2,‡, Byung Jun Ryu1, Kwang-Jin Kim2, Seong-Hee Moon1, Hyuk Lee3, Myeung Su Lee4, Sam Youn Lee5, Jin-Chul Heo6, Sang-Joon Park7 andSeong Hwan Kim1,* DOI: 10.1002/jbmr.2468Contact Us For More Information.