Hepatic Cells

ZenBio offers an assortment of various human and non-human hepatic derived cells. These include Hepatocytes, Total Liver Cell Population (TLC), Stellates, Kupffers and Intra-hepatic biliary epithelial cells (IHBEC). We offer these as cryopreserved cells for convenience. Cryopreserved cells are suitable for a variety of assays including induction, toxicity, drug metabolism and systems biology. Both adherent and suspension cells are available. Custom configurations are available upon request. Human cells are isolated from whole liver tissue obtained via the gift of organ donation from donor tissue that is not suitable for organ transplantation.

Cells have been tested for performance in viability. Cells have tested negative for HIV-1, HIV-2, HbsAG, HbcAB, HCV, and RPR. Cells are additionally tested for CMV.Some CMV positive lots are released for experiments.

Specially formulated media is available for the plating and maintenance of our cells.

Plateable lot of cryopreserved hepatocytes plated on collagen type I

Ordering Information:

Human Hepatocytes

Item#Item DescU/MPrice
HP-FCryopreserved Plateable hepatocytes from whole livers (price per million) Viable cell count varies per lotVial$244.00/million
HP-NPCryopreserved Mature Human Hepatocytes, Non-Plateable, Priced per million cells. Viable cell count varies per lot. Contact us for specific lots available and pricingVial$109.00/million
HM-1Hepatocyte Plating Medium (expiry 30 days from ship date)500ml$167.00
HM-2Hepatocyte Maintenance Medium (expiry 30 days from ship date)500ml$167.00

Human Hepatic Non-Parenchymal Cells

Item#Item DescU/MPrice
HP-F-SCryopreserved Human Hepatic Stellate Cells: 100,000 cells/vial.Vial$271.00
HSGM-250Hepatic/Pancreatic Stellate Growth Medium, 250ml250 ml$117.00
HSGM-500Hepatic/Pancreatic Stellate Growth Medium, 500ml500ml$176.00
HP-KC-FCryopreserved Human Kupffer cells, min of 1 million cells/vialVial$921.00
KC-1Kupffer Cell Plating Medium, (HUMAN) 250ml250ml$97.00
KC-2Kupffer Cell Maintenance Medium, (HUMAN) 250ml250ml$97.00
HP-F-NPCCryoperserved Non-Parenchymal Cells (NPC), Price per million cells (Uses HM-1 Medium)Vial$190.00
HSEC-FCryopreserved Human Hepatic Sinusoidal Endothelial Cells, 500,000 cells/vialVial$651.00
ECGM-1Endothelial Growth Medium, 500ml500ml$117.00
IHBEC-FCryopreserved Human Intra-Hepatic Biliary Epithelial Cells: 500,000 cells/vialVial$651.00
IHBEC-1Intra-Hepatic Biliary Epithelial Cell Growth Medium, 500ml500ml$117.00

Human Hepatic Progenitor Cells

Item#Item DescU/MPrice
HP-1Hepatic Progenitor Cell Plating Medium (expiry 30 days from ship date)500 ml$302.00
HP-2Hepatic Progenitor Cell Maintenance Medium (expiry 30 days from ship date)500 ml$302.00

Non-Human Hepatocytes

Item#Item DescU/MPrice
HPM-FCryopreserved Plateable MOUSE Hepatocytes, min of 4 million cells/vialVial$1031.00
HPR-FCryopreserved Plateable RAT Hepatocytes, min of 4 million cells/vialVial$705.00
BEA-FCryopreserved Plateable DOG (Beagle) Hepatocytes, min of 4 million cells/vialVial$922.00
HM-3Rodent Hepatocyte Plating Medium (expiry 30 days from ship date)500ml$167.00
HM-4Rodent Hepatocyte Maintenance Medium (expiry 30 days from ship date)500ml$167.00
HM-5Dog Hepatocytes Plating Medium (expiry 30 days from ship date)500ml$167.00
HM-6Dog Hepatocytes Maintenance Medium (expiry 30 days from ship date)500ml$167.00

For more information regarding our human liver products or to sign up for a HepAlert™ notification of new hepatocyte lots and updated product offerings Contact Us

To See the Hepatocyte Care and Maintenance Manual

A comprehensive list of products and prices can be found at Retail Prices(.PDF).

Recent Publications:View
Human liver spheroid cultures in microfluidic chip co-cultures and comparative MetID studies
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Maresin 1 attenuates NAFLD by suppression of endoplasmic reticulum stress via AMPK-SERCA2b pathway
Tae Woo Jung , Hyoung-Chun Kim , A.M. Abd El-Aty, Ji Hoon Jeong
The latest version is at http://www.jbc.org/cgi/doi/10.1074/jbc.RA117.000885 JBC Papers in Press. Published on February 5, 2018 as Manuscript RA117.000885
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WISP1 promotes non‐alcoholic fatty liver disease and skeletal muscle insulin resistance via TLR4/JNK signaling
Tae Woo Jung, Changmuk Kang, Jiwon Goh, Soo In Chae, Hyoung-Chun Kim, Tae Jin Lee, A. M. Abd El-Aty, Ji Hoon
DOI: 10.1002/jcp.26449
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Coordinated regulation of hepatic FoxO1, PGC-1α and SREBP-1c facilitates insulin action and resistance
Mini P. Sajan, Mackenzie C. Lee, Fabienne Foufelle, Joshua Sajan, Courtney Cleland, Robert V. Farese
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Integrin alpha 11 in the regulation of the myofibroblast phenotype: implications for fibrotic diseases
Ruchi Bansal, Shigeki Nakagawa, Saleh Yazdani, Joop van Baarlen, Anu Venkatesh, Anna P Koh, Won-Min Song, Nicolas Goossens, Hideo Watanabe, Mary B Beasley, Charles A Powell, Gert Storm, Naftali Kaminski, Harry van Goor, Scott L Friedman, Yujin Hoshida & Jai Prakash
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Hyperlipidemia-induced hepassocin in the liver contributes to insulin resistance in skeletal muscle Tae WooJung, , Hyoung-ChunKim, A.M.AbdEl-Aty, Ji HoonJeong
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An In Vitro Human Liver Model by iPSC-Derived Parenchymal and Non-parenchymal Cells Yuta Koui,Taketomo Kido, Toshimasa Ito, Hiroki Oyama, Shin-Wei Chen, Yuki Katou, Katsuhiko Shirahige, and Atsushi Miyajima
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Microengineered cultures containing human hepatic stellate cells and hepatocytes for drug development Matthew Davidson, David A Kukla and Salman Khetani
Integr. Biol., 2017, DOI:10.1039/C7IB00027H
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Protectin DX suppresses hepatic gluconeogenesis through AMPK-HO-1-mediated inhibition of ER stress Tae Woo Junga, Hyung-Chun Kimb, Ji Hoon Jeongc
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In vitro toxicological evaluation of NCS-382, a high-affinity antagonist of γ-hydroxybutyrate (GHB) binding KR Vogela, GR Ainsliea, J-B Roulleta, A McConnellb, KM Gibson
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Inhibition of Adhesion Molecule Gene Expression and Cell Adhesion by the Metabolic Regulator PGC-1α Neri Minsky, Robert G. Roeder
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Resveratrol exerts a biphasic effect on apolipoprotein M Makoto Kurano, Masumi Hara, Takahiro Nojiri, Hitoshi Ikeda, Kazuhisa Tsukamoto and Yutaka Yatomi
DOI: 10.1111/bph.13360
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C1q/TNF-Related Protein 9 (CTRP9) attenuates hepatic steatosis via the autophagy-mediated inhibition of endoplasmic reticulum stress Tae Woo Jung, Ho Cheol Hong, Hwan-Jin Hwang, Hye Jin Yoo, Sei Hyun Baik, Kyung Mook Choi
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Gastrointestinal Fibroblasts Have Specialized, Diverse Transcriptional Phenotypes: A Comprehensive Gene Expression Analysis of Human Fibroblasts Youichi Higuchi , Motohiro Kojima , Genichiro Ishii, Kazuhiko Aoyagi, Hiroki Sasaki, Atsushi Ochiai
Published: June 5, 2015DOI: 10.1371/journal.pone.0129241
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Hepatic stellate cells express thymosin Beta 4 in chronically damaged liver. Jieun Kim, Sihyung Wang, Jeongeun Hyun, Steve S. Choi, Heejae Cha, Meesun Ock, Youngmi Jung
Published: March 31, 2015DOI: 10.1371/journal.pone.0122758
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Preadipocytes Mediate Lipopolysaccharide-Induced Inflammation and Insulin Resistance in Primary Cultures of Newly Differentiated Human Adipocytes. Soonkyu Chung, Kathleen LaPoint, Kristina Martinez, Arion Kennedy, Maria Boysen Sandberg, and Michael K. McIntosh Endocrinology, Nov 2006; 147: 5340 - 5351. download pdf
Ritonavir, Saquinavir, and Efavirenz, but Not Nevirapine, Inhibit Bile Acid Transport in Human and Rat Hepatocytes. Mary Peace McRae, Carolina M. Lowe, Xianbin Tian, David L. Bourdet, Richard H. Ho, Brenda F. Leake, Richard B. Kim, Kim L. R. Brouwer, and Angela D. M. Kashuba J. Pharmacol. Exp. Ther., Sep 2006; 318: 1068 - 1075. download pdf
The Use of Whole Organ Decellularization for the Generation of a Vascularized Liver Organoid Pedro M. Baptista,1* Mohummad M. Siddiqui,2* Genevieve Lozier,3 Sergio R. Rodriguez,1,4 Anthony Atala,1 and Shay Soker download pdf
Essential Role of Endocytosis of the Type II Transmembrane Serine Protease TMPRSS6 in Regulating Its Functionality* Francois Béliveau, Cédric Brulé, Antoine D&ecute;silets, Brandon Zimmerman, Stéphane A. Laporte Christine L. Lavoie and Richard Leduc August 19, 2011 The Journal of Biological Chemistry, 286,29035-29043
Soluble CLEC2 Extracellular Domain Improves Glucose and Lipid Homeostasis by Regulating Liver Kupffer Cell Polarization X Wu, J Zhang, H Ge, J Gupte, H Baribault, KJ Lee ... - EBioMedicine, 2015 download pdf