Visceral Preadipocytes and Adipocytes
Metabolic disease is associated more closely with the accumulation of abdominal adipose in specific visceral depots. Recent studies have implicated omental and mesenteric adipose tissue in obesity-related insulin resistance, atherosclerosis, and type 2 diabetes. To provide the most relevant systems for investigating obesity-related morbidities, Zen-Bio is offering visceral derived human preadipocytes and cultured adipocytes to the research community.
Preadipocytes are isolated from omental, mesenteric, or perirenal adipose tissue and are tested for their ability to differentiate in culture to mature adipocytes. Preadipocytes are available cryopreserved or plated and mature adipocytes are available in a variety of plated formats.
Most cells are derived from obese patients (BMI>30), but there are limited quantities of preadipocytes and adipocytes from patients of BMI <27. Lots derived from multiple patients are also available as Pooled- or Super-lots.
There are limited quantities of donor matched omental and subcutaneous preadipocytes or cultured adipocytes for studies comparing the two depots.
OMENTAL ADIPOSE
The greater omentum is the largest peritoneal fold within the abdomen and has an immunologic function. The omentum aids in isolating peritoneal infection and absorbing contaminants through the mesothelial stomata. Adipokines and fatty acids from this depot have direct access to the liver through the portal circulation which may lead to hepatic dysfunction.
MESENTERIC ADIPOSEMesenteric adipose lies within the thin layers of the peritoneal mesothelium connecting the small and large intestine. Adipose accumulation within this depot correlates with an increased risk of metabolic disease.
PERIRENAL ADIPOSEPerirenal adipose resides near the kidneys outside the peritoneal cavity. Fat from this depot has not been correlated with increased risk for metabolic disease.
Ordering Information:
Preadipocytes
| Item | BMI | Cat# | Price |
|---|---|---|---|
| Omental Preadipocytes 6-Well Plate | >30.0 | OP-2006-3 | $875.00 |
| Omental Preadipocytes 12-Well Plate | >30.0 | OP-2012-3 | $875.00 |
| Omental Preadipocytes 24-Well Plate | >30.0 | OP-2024-3 | $875.00 |
| Omental Preadipocytes 48-Well Plate | >30.0 | OP-2048-3 | $875.00 |
| Omental Preadipocytes 96-Well Plate | >30.0 | OP-2096-3 | $700.00 |
| Omental preadipocytes 25 cm2 flask | >30.0 | OP-25-3 | $700.00 |
| Omental preadipocytes 75 cm2 flask | >30.0 | OP-75-3 | $1,150.00 |
| Cryopreserved, omental (per 1x106 cells) | >30.0 | OP-F-3 | $410.00 |
| Matched Set subcutaneous and omental, cryopreserved | >30 | MS-F-3 | $1,650.00 |
| Item | BMI | Cat# | Price |
|---|---|---|---|
| Cryopreserved peri-renal (per 1x106 cells) | varies | PR-F | $410.00 |
| Cryopreserved mesenteric (per 1x106 cells) | varies | MSN-F | $410.00 |
Adipocytes
| Item | BMI | Cat# | Price |
|---|---|---|---|
| Omental Adipocytes 6-Well Plate | >30.0 | OA-1006-3 | $1,050 |
| Omental Adipocytes 12-Well Plate | >30.0 | OA-1012-3 | $1,050 |
| Omental Adipocytes 24-Well Plate | >30.0 | OA-1024-3 | $1,050 |
| Omental Adipocytes 48-Well Plate | >30.0 | OA-1048-3 | $1,050 |
| Omental Adipocytes 96-Well Plate | >30.0 | OA-1096-3 | $850 |
| Omental Adipocytes 25 cm2 flask | >30.0 | OA-25 | $850 |
| Omental Adipocytes 75 cm2 flask | >30.0 | OA-75 | $1,350 |
