Regulation of the bi-directional cross-talk between ovarian cancer cells and adipocytes by SPARC
Bincy John, Christine Naczki, Chirayu Patel, Alia Ghoneum, Shadi Qasem, Ziyan Salih & Neveen SaidDOI: https://doi.org/10.1038/s41388-019-0728-3
Visceral Preadipocytes and AdipocytesMetabolic disease is associated more closely with the accumulation of abdominal adipose in specific visceral depots. Recent studies have implicated omental and mesenteric adipose tissue in obesity-related insulin resistance, atherosclerosis, and type 2 diabetes. To provide the most relevant systems for investigating obesity-related morbidities, ZenBio is offering visceral derived human preadipocytes and cultured adipocytes to the research community. ![]() Preadipocytes are isolated from omental, mesenteric, or perirenal adipose tissue and are tested for their ability to differentiate in culture to mature adipocytes. Preadipocytes are available cryopreserved or plated and mature adipocytes are available in a variety of plated formats. Most cells are derived from obese non-diabetic patients (BMI>30), but there are limited quantities of preadipocytes and adipocytes from patients of BMI <27 as well as some lots of cells available from diabetic patients. Lots derived from multiple patients are also available as Pooled- or Super-lots. There are limited quantities of donor matched omental and subcutaneous preadipocytes or cultured adipocytes for studies comparing the two depots. OMENTAL ADIPOSEThe greater omentum is the largest peritoneal fold within the abdomen and has an immunologic function. The omentum aids in isolating peritoneal infection and absorbing contaminants through the mesothelial stomata. Adipokines and fatty acids from this depot have direct access to the liver through the portal circulation which may lead to hepatic dysfunction. MESENTERIC ADIPOSEMesenteric adipose lies within the thin layers of the peritoneal mesothelium connecting the small and large intestine. Adipose accumulation within this depot correlates with an increased risk of metabolic disease. PERIRENAL ADIPOSEPerirenal adipose resides near the kidneys outside the peritoneal cavity. Fat from this depot has not been correlated with increased risk for metabolic disease. Specially formulated media are available for use with our omental preadipocytes and adipocytes. Ordering Information:Preadipocytes
Adipocytes
Visceral Omental Adipocyte Care Manual Contact Us For More Information. A comprehensive list of products and prices can be found at Retail Prices(.PDF). Visceral Preadipocytes and Adipocytes PublicationsRegulation of the bi-directional cross-talk between ovarian cancer cells and adipocytes by SPARCBincy John, Christine Naczki, Chirayu Patel, Alia Ghoneum, Shadi Qasem, Ziyan Salih & Neveen SaidDOI: https://doi.org/10.1038/s41388-019-0728-3 Renewable Source of Human Beige Adipocytes for Development of Therapies to Treat Metabolic SyndromeSu Su, Anyonya R.Guntur, Daniel C. Nguyen, Shameem S. Fakory, Chad C. Doucette, Cassandra Leech, Humphrey Lotana, Matthew Kelley, Jaspreet Kohli, Julieta Martino, Sunder Sims-Lucas, Lucy Liaw, Calvin Vary, Clifford J. Rosen, Aaron C. Brownhttps://doi.org/10.1016/j.celrep.2018.11.037 Adipose TSHB in Humans and Serum TSH in Hypothyroid Rats Inform About Cellular SenescenceMoreno-Navarrete J.M., Li&numl;ares-Pose L., Sabater M., Rial-Pensado E., Comas F. , Jové M.,Latorre J., Ortega F., Ricart W. , Portero-Otin M. , López M. , Fernández-Real J.M.Cell Physiol Biochem 2018;51:142–153 https://doi.org/10.1159/000495170 β-aminoisobutyric acid attenuates LPS-induced inflammation and insulin resistance in adipocytes through AMPK-mediated pathwayTae Woo Jung, Hyung Sub Park, Geum Hee Choi, Daehwan Kim and Taeseung Leehttps://doi.org/10.1186/s12929-018-0431-7 Effects of exosomes from LPS-activated macrophages on adipocyte gene expression, differentiation, and insulin-dependent glucose uptakeDe Silva, N., Samblas, M., MartÃnez, J.A. et al. J Physiol Biochem (2018).https://doi.org/10.1007/s13105-018-0622-4 Intrinsic Properties of Brown and White Adipocytes Have Differential Effects on Macrophage Inflammatory ResponsesLouisa Dowal, Pooja Parameswaran, Sarah Phat, Syamala Akella, Ishita Deb Majumdar, Jyoti Ranjan, Chahan Shah, Saie Mogre, Kalyani Guntur, Khampaseuth Thapa, Stephane Gesta, Vivek K Vishnudas, Niven R. Narain and Rangaprasad Sarangarajan Berg, LLCResistin exposure of human omental adipocytes affects transcriptional regulation processes involved in cellular differentiation and maintenance.Sotiriou, AlexandrosUniversity. Promotor(en): Ivonne Rietjens, co-promotor(en): Jacques Vervoort. - Wageningen : Wageningen University - ISBN 9789463430302 - 137 p Hydroxytyrosol, an ingredient of olive oil, reduces triglyceride accumulation and promotes lipolysis in human primary visceral adipocytes during differentiationBruno Stefanon, Monica ColittiExp Biol Med (Maywood) June 10, 2016 1535370216654226 Chemokine profiles of human visceral adipocytes from cryopreserved preadipocytes: Neutrophil activation and induction of nuclear factor-kappa B repressing factorRui Yamaguchia, b, Takatoshi Yamamotoa, Arisa Sakamotoa, Yasuji Ishimarua, Shinji Naraharaa, Hiroyuki Sugiuchia, Yasuo Yamaguchidoi:10.1016/j.lfs.2015.11.010, LifeSciences Capillary Isoelectric Focusing Immunoassay for Fat Cell Differentiation ProteomicsMary G. Johlfs, Priyatham Gorjala, Yasuyo Urasaki, Thuc T. Le , Ronald R. FiscusPublished: July 1, 2015DOI: 10.1371/journal.pone.0132105 Effects of Two Different Rhodiola rosea Extracts on Primary Human Visceral AdipocytesElena Pomari, Bruno Stefanon and Monica ColittiMolecules 2015, 20, 8409-8428; doi:10.3390/molecules20058409 Inflammatory Cytokines Link Obesity and Breast CancerNalin Siriwardhana1, Rett Layman2, Ayub Karwandyar2, Shiwani Patel2, Blair Tage2, Matthew Clark2, Jessica Lampley2, Courtney Rhody2, Erica Smith2, Arnold M Saxton1, Naima Moustaid-Moussa1* and Jay Wimalasena2Journal of Metabolic Syndrome, March 2015 Circulating Pigment Epithelium-Derived Factor Levels Are Associated with Insulin Resistance and Decrease after Weight Loss.Sabater M, Moreno-Navarrete JM, Ortega FJ, Pardo G, Salvador J, Ricart W, Frühbeck G, Fernández-Real JM 2010 J Clin Endocrinol Metab 95:4720-4728.Synthesis and Secretion of Plasminogen Activator Inhibitor-1 by Human Preadipocytes.David L. Crandall, Elaine M. Quinet, Gwen A. Morgan, Dennis E. Busler, Barbara McHendry-Rinde, and John G. Kral J. Clin. Endocrinol. Metab., Sep 1999; 84: 3222 - 3227.Study of the proinflammatory role of human differentiated omental adipocytes.Bassols, J., Ortega, F. J., Moreno-Navarrete, J. M., Peral, B., Ricart, W. and Fernández-Real, J.-M. (2009), Journal of Cellular Biochemistry, 107: 110-1117. doi: 10.1002/jcb.22208.LIGHT is associated with hypertriglyceridemia in obese subjects and increased cytokine secretion from cultured human adipocytes.Bassols J, Moreno-Navarrete JM, Ortega F, Ricart W, Fernandez-Real JM (2010) Int J Obes 34:146-156.Characterization of herpes virus entry mediator as a factor linked to obesity.Bassols J, Moreno JM, Ortega F, Ricart W, Fernandez-Real JM (2010) Obesity 18(2): 239-46. doi:10.1038/oby.2009.250.Attenuated metabolism is a hallmark of obesity as revealed by comparative proteomic analysis of human omental adipose tissueRafael Pérez-Pérez, Eva Garcia-Santos, Francisco J. Ortega-Delgado, Juan A. Lopez, Emilio Camafeita, Wifredo Ricart, José-Manuel Fernández-Real, Belén Peral.METHODS AND MATERIALS RELATED TO NUTRITIONAL SUPPLEMENT COMPOSITIONS CONTAINING A POTATO POLYSACCHARIDE PREPARATION |
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