Subcutaneous Preadipocytes and Adipocytes

ZenBio provides the highest quality primary human cultured preadipocytes and adipocytes. Our cells have multiple applications in basic research, drug screening and development.

Cells are isolated from a wide variety of patients with good representation from all levels of adiposity and age. Cells are available from both male and female donors. Pooled lots of cells are available from both male and female donors to provide large lots for screening and to decrease issues with patient to patient variability.

Preadipocytes are provided cryopreserved or in culture. Adipocytes are differentiated in vitro from preadipocytes using our patent protected differentiation methods. Cells are available in a variety of plate formats.

All cells have passed our rigorous quality control measures including performance in lipid accumulation, lipolysis, and adipokine secretion. Cells have tested negative for HIV-1, HIV-2, HTLV-1, HTLV-2, Hepatitis B, Hepatitis C and mycoplasma.

Specially formulated media are available for use with our subcutaneous preadipocytes and adipocytes.

Subcutaneour Adipocytes

Subcutaneous adipocytes at two weeks post differentiation. Stained with the neutral lipid dye Oil Red O.

Subcutaneous preadipocytes in culture. Phase contrast image.

Ordering Information:

Cultured Subcutaneous Adipocytes+ (*All Adipocytes have a 2 week lead time for differentiation)

Item#Item DescU/MPrice
SA-1006-1Subcutaneous Adipocytes 6-Well Plate, BMI <24.99Each$585.00
SA-1006-2Subcutaneous Adipocytes 6-Well Plate, BMI 25.0-29.99Each$585.00
SA-1006-3Subcutaneous Adipocytes 6-Well Plate, BMI >30.0Each$585.00
SA-1006-SLSubcutaneous Adipocytes 6-Well Plate (POOLED Donor Lot)Each$585.00
SA-1012-1Subcutaneous Adipocytes 12-Well Plate, BMI <24.99Each$585.00
SA-1012-2Subcutaneous Adipocytes 12-Well Plate, BMI 25.0-29.99Each$585.00
SA-1012-3Subcutaneous Adipocytes 12-Well Plate, BMI >30.0Each$585.00
SA-1012-SLSubcutaneous Adipocytes 12-Well Plate, (POOLED Donor Lot)Each$585.00
SA-1024-1Subcutaneous Adipocytes 24 Well Plate, BMI <24.99Each$585.00
SA-1024-2Subcutaneous Adipocytes 24 Well Plate, BMI 25.0-29.99Each$585.00
SA-1024-3Subcutaneous Adipocytes 24 Well Plate, BMI >30.0Each$585.00
SA-1024-SLSubcutaneous Adipocytes 24 Well Plate, (POOLED Donor Lot)Each$585.00
SA-1048-1Subcutaneous Adipocytes 48-Well Plate, BMI <24.99Each$585.00
SA-1048-2Subcutaneous Adipocytes 48-Well Plate, BMI 25.0-29.99Each$585.00
SA-1048-3Subcutaneous Adipocytes 48-Well Plate, BMI >30.0Each$585.00
SA-1048-SLSubcutaneous Adipocytes 48-Well Plate, (POOLED Donor Lot)Each$585.00
SA-1096-1Subcutaneous Adipocytes 96-Well Plate, BMI <24.99Each$585.00
SA-1096-2Subcutaneous Adipocytes 96-Well Plate, BMI 25.0-29.99Each$585.00
SA-1096-3Subcutaneous Adipocytes 96-Well Plate, BMI >30.0Each$585.00
SA-1096-SLSubcutaneous Adipocytes 96-Well Plate, (POOLED Donor Lot)Each$585.00
SA-25-1Subcutaneous Adipocytes 25 cm2 Flask, BMI <24.99Each$585.00
SA-25-2Subcutaneous Adipocytes 25 cm2 Flask, BMI 25.0-29.99Each$585.00
SA-25-3Subcutaneous Adipocytes 25 cm2 Flask, BMI >30.0Each$585.00
SA-25-SLSubcutaneous Adipocytes 25 cm2 Flask, (POOLED Donor Lot)Each$585.00
SA-75-1Subcutaneous Adipocytes 75 cm2 Flask, BMI <24.99Each$856.00
SA-75-2Subcutaneous Adipocytes 75 cm2 Flask, BMI 25.0-29.99Each$856.00
SA-75-3Subcutaneous Adipocytes 75 cm2 Flask, BMI >30.0Each$856.00
SA-75-SLSubcutaneous Adipocytes 75 cm2 Flask, (POOLED Donor Lot)Each$856.00

Cultured Subcutaneous Preadipocytes

Item#Item DescU/MPrice
SP-2006-1Subcutaneous Preadipocytes 6-Well Plate. BMI <24.99Each$444.00
SP-2006-2Subcutaneous Preadipocytes 6-Well Plate. BMI 25.0-29.99Each$444.00
SP-2006-3Subcutaneous Preadipocytes 6-Well Plate. BMI >30Each$444.00
SP-2006-SLSubcutaneous Preadipocytes 6-Well Plate, (POOLED Donor Lot)Each$444.00
SP-2012-1Subcutaneous Preadipocytes 12-Well Plate. BMI <24.99Each$444.00
SP-2012-2Subcutaneous Preadipocytes 12-Well Plate. BMI 25.0-29.99Each$444.00
SP-2012-3Subcutaneous Preadipocytes 12-Well Plate. BMI >30.0Each$444.00
SP-2012-SLSubcutaneous Preadipocytes, 12-Well Plate, (POOLED Donor Lot)Each$444.00
SP-2024-1Subcutaneous Preadipocytes 24-Well Plate. BMI <24.99Each$444.00
SP-2024-2Subcutaneous Preadipocytes 24-Well Plate. BMI 25.0-29.99Each$444.00
SP-2024-3Subcutaneous Preadipocytes 24-Well Plate. BMI >30.0Each$444.00
SP-2024-SLSubcutaneous Preadipocytes 24-Well Plate, (POOLED Donor Lot)Each$444.00
SP-2048-1Subcutaneous Preadipocytes 48-Well Plate. BMI <24.99Each$444.00
SP-2048-2Subcutaneous Preadipocytes 48-Well Plate. BMI 25.0-29.99Each$444.00
SP-2048-3Subcutaneous Preadipocytes 48-Well Plate. BMI >30.0Each$444.00
SP-2048-SLSubcutaneous Preadipocytes 48-Well Plate, (POOLED Donor Lot)Each$444.00
SP-2096-1Subcutaneous Preadipocytes 96-Well Plate. BMI <24.99Each$444.00
SP-2096-2Subcutaneous Preadipocytes 96-Well Plate. BMI 25.0-29.99Each$444.00
SP-2096-3Subcutaneous Preadipocytes 96-Well Plate. BMI >30.0Each$444.00
SP-2096-SLSubcutaneous Preadipocytes 96-Well Plate, (POOLED Donor Lot)Each$444.00
SP-25-1Subcutaneous Preadipocytes 25 cm2 Flask. BMI <24.99Each$444.00
SP-25-2Subcutaneous Preadipocytes 25 cm2 Flask. BMI 25.0-29.99Each$444.00
SP-25-3Subcutaneous Preadipocytes 25 cm2 Flask. BMI >30.0Each$444.00
SP-25-SLSubcutaneous Preadipocytes 25 cm2 Flask, (POOLED Donor Lot)Each$444.00
SP-75-1Subcutaneous Preadipocytes 75 cm2 Flask. BMI <24.99Each$646.00
SP-75-2Subcutaneous Preadipocytes 75 cm2 Flask. BMI 25.0-29.99Each$646.00
SP-75-3Subcutaneous Preadipocytes 75 cm2 Flask. BMI >30.0Each$646.00
SP-75-SLSubcutaneous Preadipocytes 75 cm2 Flask, (POOLED Donor Lot)Each$646.00
SP-F-1Cryopreserved, Subcutaneous Preadipocytes (2 million cells/vial) BMI<24.99Vial$429.00
SP-F-2Cryopreserved, Subcutaneous Preadipocytes (2 million cells/vial) BMI 25.0-29.99Vial$429.00
SP-F-3Cryopreserved, Subcutaneous Preadipocytes (2 million cells/vial) BMI >30.0Vial$429.00
SP-F-SLCryopreserved, Subcutaneous Preadipocytes, POOLED Lot (2 million cells/vial) BMI 25.0-29.99Vial$429.00
SPD-F-1Cryopreserved, Subcutaneous Preadipocytes, DIABETIC (1 million cells/vial) BMI<24.99Vial$792.00
SPD-F-2Cryopreserved, Subcutaneous Preadipocytes, DIABETIC (1 million cells/vial) BMI 25.0-29.99Vial$792.00
SPD-F-3Cryopreserved, Subcutaneous Preadipocytes, DIABETIC (1 million cells/vial) BMI >30.0Vial$792.00
BR-FCryopreserved, Subcutaneous BREAST Preadipocytes (1 million cells/vial)Vial$292.00
SQE-FCryopreserved, Subcutaneous Facial Preadipocytes (1 million cells/vial)Vial$495.00
MSND-FPreadipocytes isolated from Mesenteric Adipose Tissue. DIABETIC Donor,1 million cells per vialVial$714.00

Contact Us For More Information

To See the Adipocyte Care and Maintenance Manual

A comprehensive list of products and prices can be found at Retail Prices (.PDF).

Recent Publications: AdipocytesView
MicroRNA-140 Regulation of the Mammary Microenvironment
Benjamin R. Wolfson
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Browning of white adipose tissue induced by the β3 agonist CL-316,243 after local and systemic treatment-PK-PD relationship
Wojciech Danysz, Yan Han, Fugang Li, Jim Nicoll, Philipp Buch, Thomas Hengl, Maarten Ruitenberg, Chris Parsons
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Adipocytes impair efficacy of antiretroviral therapy
Jacob Couturiera, Lee C. Winchesterb, James W. Suliburkc, Gregory K. Wilkersond, Anthony T. Podanyb, Neeti Agarwale, Corrine Ying Xuan Chuaf, Pramod N. Neheted, Bharti P. Neheted, Alessandro Grattonif, K. Jagannadha Sastryg, Courtney V. Fletcherb, Jordan E. Lakea, Ashok Balasubramanyane, Dorothy E. Lewisa
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Protectin DX attenuates LPS-induced inflammation and insulin resistance in adipocytes via AMPK-mediated suppression of the NFκB pathway
Tae Woo Jung, Yoon Hee Chung, Hyoung-Chun Kim, A. M. Abd El-Aty, and Ji Hoon Jeong
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Insight into the development of obesity: functional alterations of adipose-derived mesenchymal stem cells
F. Louwen, A. Ritter, N. N. Kreis, J. Yuan
DOI: 10.1111/obr.12679
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Statins decrease leptin expression in human white adipocytes
Prachi Singh, Yuebo Zhang, Pragya Sharma, Naima Covassin, Filip Soucek, Paul A. Friedman, Virend K. Somers
DOI: 10.14814/phy2.13566
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Developmental Programming: Impact of Prenatal Testosterone Excess on Steroidal Machinery and Cell Differentiation Markers in Visceral Adipocytes of Female ...
Muraly Puttabyatappa, PhD, Chunxia Lu, PhD, Jacob D. Martin, Gregorio Chazenbalk, PhD, Daniel Dumesic, MD, Vasantha Padmanabhan, PhD
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The Effects of Hypoxia on Human Adipose Tissue Lipid Storage and Mobilization Functions: From Primary Cell Culture to Healthy Men Bimit Mahat download pdf
Heme Biosynthetic Pathway is Functionally Linked to Adipogenesis via Mitochondrial Respiratory Activity José María Moreno-Navarrete, Amaia Rodríguez, Francisco Ortega, Sara Becerril, Jordi Girones, Mónica Sabater-Masdeu, Jéssica Latorre, Wifredo Ricart, Gema Frühbeck, José Manuel Fernández-Real
DOI: 10.1002/oby.21956
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A novel botanical formula prevents diabetes by improving insulin resistance Juntao Kan, Rodney A. Velliquette, Kerry Grann, Charlie R. Burns, Jeff Scholten, Feng Tian, Qi Zhang and Min Gui BMC Complementary and Alternative MedicineBMC series – open, inclusive and trusted201717:352
DOI: 10.1186/s12906-017-1848-3
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Impact of antibody subclass and disulfide isoform differences on the biological activity of CD200R and βklotho agonist antibodies Ognjen Grujica, Jennitte Stevensb, Robert Y.-T. Choub, Jennifer V. Weiszmannc, Laura Sekirova, Christy Thomsona, Anita Badha, Stephanie Grauera, Brian Chana, Kevin Grahamb, Kathy Manchulenkoa, Thomas M. Dillonb, Yang Lic, Ian N. Foltza,
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Adipocyte lipolysis links obesity to breast cancer growth: adipocyte-derived fatty acids drive breast cancer cell proliferation and migration Seher Balaban, Robert F. Shearer, Lisa S. Lee, Michelle van Geldermalsen, Mark Schreuder, Harrison C. Shtein, Rose Cairns, Kristen C. Thomas, Daniel J. Fazakerley, Thomas Grewal, Jeff Holst, Darren N. Saunders and Andrew J. Hoy
Cancer & Metabolism20175:1
DOI: 10.1186/s40170-016-0163-7
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Cellular response of osteoblasts to low modulus Ti-24Nb-4Zr-8Sn alloy mesh structure K. C. Nune, R. D. K. Misra, S. J. Li, Y. L. Hao, R. Yang
DOI: 10.1002/jbm.a.35963
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Cellular Aging Contributes to Failure of Cold-Induced Beige Adipocyte Formation in Old Mice and Humans Daniel C. Berry1, Yuwei Jiang, Robert W. Arpke, Elizabeth L. Close, Aki Uchida, David Reading, Eric D. Berglund, Michael Kyba, Jonathan M. Graff
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Assessing the Relationship between Sports Participation and Self-Esteem among Middle-School Students E.A. Whitney, College of Education, Dept. of Kinesiology & Health Promotion, U of Kentucky M. Kidd
11th Annual CCTS Spring Conference.
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Cardiotrophin‐1 Regulates Adipokine Production in 3T3‐L1 Adipocytes and Adipose Tissue from Obese Mice Miguel López-Yoldi, Beatriz Marcos-Gomez, M. Asunción Romero-Lozano, Neira Sáinz, Jesús Prieto, J. Alfredo Martínez, Matilde Bustos, Maria J. Moreno-Aliaga
DOI: 10.1002/jcp.25590
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Beyond thermoregulation: metabolic function of cetacean blubber in migrating bowhead and beluga whales H. C. Ball, R. L. Londraville, J. W. Prokop, John C. George, R. S. Suydam, C. Vinyard, J. G. M. Thewissen, R. J. Duff
DOI: 10.1007/s00360-016-1029-6
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Hypoxia Alters the Expression of Dipeptidyl Peptidase 4 and Induces Developmental Remodeling of Human Preadipocytes Helena H. Chowdhury, Jelena Velebit, Nataša Radić, Vito Frančič, Marko Kreft, and Robert Zorec
Journal of Diabetes Research
Article ID 7481470
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Melanocortin agonists stimulate lipolysis in human adipose tissue explants but not in adipocytes Cathrine Laustrup Møller, Steen B. Pedersen, Bjørn Richelsen, Kilian W. Conde-Frieboes, Kirsten Raun, Kevin L. Grove7 and Birgitte Schjellerup Wulff
BMC Research Notes 2015, 8:559 doi:10.1186/s13104-015-1539-4
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miR-140 Promotes Expression of long non-coding RNA NEAT1 in Adipogenesis Ramkishore Gernapudi, Benjamin Wolfson, Yongshu Zhang, Yuan Yao, Peixin Yang, Hiroshi Asahara and Qun Zhou
ASM doi:10.1128/MCB.00702-15
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Characterization of key genes of the renin–angiotensin system in mature feline adipocytes and during in vitro adipogenesis J. Riedel, B. Badewien-Rentzsch, B. Kohn, L. Hoeke and R. Einspanier
DOI: 10.1111/jpn.12392
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MiR-93 Controls Adiposity via Inhibition of Sirt7 and Tbx3 Michele Cioffi, Mireia Vallespinos-Serrano, Sara M. Trabulo, ..., Anne Moon, Alexandra Aicher, Christopher Heeschen
Cioffi et al., 2015, Cell Reports 12, 1–12 September 8, 2015 a2015 The Authors
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Ubc9 impairs activation of the brown fat energy metabolism program in human white adipocytes Sean M. Hartig, David A. Bader , Kathleen V. Abadie , Massoud Motamed , Mark P. Hamilton , Weiwen Long, Brian York , Michaela Mueller , Martin Wagner , Michael Trauner , Lawrence Chan, Mandeep Bajaj , David D. Moore , Michael A. Mancini , Sean E. McGuire
Molecular Endocrinology, ISSN Print 0888-8809 ISSN Online 1944-9917
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Subetta increases phosphorylation of insulin receptor β-subunit alone and in the presence of insulin E A Gorbunov, J Nicoll, E V Kachaeva, S A Tarasov and O I Epstein
Nutrition & Diabetes (2015) 5, e169; doi:10.1038/nutd.2015.20
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Oxidative activity of 17β-hydroxysteroid dehydrogenase on testosterone in male abdominal adipose tissues and cellular localization of 17β-HSD type 2 Mohamed Fouad Mansoura, Mèlissa Pelletiera, Marie-Michèle Bouleta, b, Dominique Mayrandc, d, Gaétan Brochue, Stefane Lebelb, Donald Poiriera, Julie Fradettec, d, Katherine Cianfloneb, Van Luu-Thea, André Tchernof
doi:10.1016/j.mce.2015.06.016, Molecular and Cellular Endocrinology June 2015
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Methacrylated gelatin and mature adipocytes are promising components for adipose tissue engineering Birgit Huber, Kirsten Borchers,Günter EM Tovar, Petra J Kluger
Biomater Appl May 27, 2015 0885328215587450
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Pharmacological properties of acid N‐thiazolylamide FFA2 agonists Andrew J. Brown1,*, Christina Tsoulou1, Emma Ward1, Elaine Gower2, Nisha Bhudia1, Forhad Chowdhury1, Tony W. Dean3, Nicolas Faucher4, Akanksha Gangar4 andSimon J. Dowell1
Article first published online: 8 MAY 2015, Pharmacology Research Perspectives
DOI: 10.1002/prp2.141
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Apelin enhances brown adipogenesis and browning of white adipocytes Aung Than , Hui Ling He , Si Hui Chua , Dan Xu , Lei Sun , Melvin Khee-Shing Leow , Peng Chen
Journal of Biological Chemistry, 2015
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Pathogenesis of pancreatic cancer exosome-induced lipolysis in adipose tissueGunisha Sagar, Raghuwansh P Sah, Naureen Javeed, Shamit K Dutta, Thomas C Smyrk, Julie S Lau, Nino Giorgadze, Tamar Tchkonia, James L Kirkland, Suresh T Chari, Debabrata Mukhopadhyay
Gut doi:10.1136/gutjnl-2014-308350
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Inflammation triggers specific microRNA profiles in human adipocytes and macrophages and in their supernatants Clinical Epigenetics Sample doi:10.1186/s13148-015-0083-3 download pdf
Subetta Treatment Increases Adiponectin Secretion by Mature Human Adipocytes In Vitro Jim Nicoll,1 Evgeniy A. Gorbunov,2 Sergey A. Tarasov,2 and Oleg I. Epstein2 download pdf
Dysregulated Alternative Splicing Pattern of PKC during Differentiation of Human Preadipocytes Represents Distinct Differences between Lean and Obese Adipocytes Gay Carter,1 André Apostolatos,2 Rekha Patel,2 Abhishek Mathur,1 Denise Cooper,1,2 Michel Murr,1,3 and Niketa A. Patel1,2 download pdf
1,25-Dihydroxyvitamin D3 Modulation of Adipocyte Glucocorticoid Function. Kristin L. Morris and Michael B. Zemel Obes. Res., Apr 2005; 13: 670 - 677. download pdf
Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin resistant mouse models----Association with liver and adipose tissue effects J. Xu, S. Stanislaus, N. Chinookoswong, Y. Y. Lau, T. Hager, J. Patel, H. Ge, J. Weiszmann, S. C. Lu, M. Graham, J. Busby, R. Hecht, Y. S. Li, Y. Li, R. A. Lindberg and M. M. Veniant Am J Physiol Endocrinol Metab. 2009; Epub ahead of print download pdf
Adipose tissue mass is modulated by SLUG (SNAI2) Pedro Antonio Pérez-Mancera, Camino Bermejo-Rodríguez, Inés Gonzaález-Herrero, Michel Herranz, Teresa Flores, Rafael Jiménez, and Isidro Sánchez-García Hum. Mol. Genet., Dec 2007; 16: 2972 - 2986. download pdf
Genistein inhibits differentiation of primary human adipocytes H. J. Park, M. A. Della-Fera, D. B. Hausman, S. Rayalam, S. Ambati and C. A. Baile J Nutr Biochem. 2009; 20 (2): 140-8. download pdf
Conjugated Linoleic Acid Induces Human Adipocyte Delipidation: AUTOCRINE/PARACRINE REGULATION OF MEK/ERK SIGNALING BY ADIPOCYTOKINES J. Mark Brown, Maria Sandberg Boysen, Soonkyu Chung, Olowatoyin Fabiyi, Ron F. Morrison, Susanne Mandrup, and Michael K. McIntosh J. Biol. Chem., Jun 2004; 279: 26735 - 26747. download pdf
Hormonal regulation of interleukin-6 production in human adipocytes V. Vicennati, A. Vottero, C. Friedman, D.A. Papanicolaou Int. J. Obesity, July 2002; 26: 905-911 download pdf
Intracellular infections enhance interleukin-6 and plasminogen activator inhibitor 1 production by cocultivated human adipocytes and THP-1 monocytes J. J. Bouwman, R. J. Diepersloot and F. L. Visseren Clin Vaccine Immunol. 2009; 16 (8): 1222-7. download pdf
Isomer-specific regulation of metabolism and PPAR signaling by CLA in human preadipocytes. J. Mark Brown, Maria Sandberg Boysen, Søren Skov Jensen, Ron F. Morrison, Jayne Storkson, Renee Lea-Currie, Michael Pariza, Susanne Mandrup, and Michael K. McIntosh J. Lipid Res., Jul 2003; 44: 1287. download pdf
Modulation of 11β-Hydroxysteroid Dehydrogenase Type 1 in Mature Human Subcutaneous Adipocytes by Hypothalamic Messengers. Mark Friedberg, Emmanouil Zoumakis, Naoki Hiroi, Tarif Bader, George P. Chrousos, and Ze'ev Hochberg J. Clin. Endocrinol. Metab., Jan 2003; 88: 385 - 393. download pdf
Regulation of adiponectin release and demonstration of adiponectin mRNA as well as release by the non-fat cells of human omental adipose tissue. J. N. Fain, B. Buehrer, D. S. Tichansky and A. K. Madan Int J Obes (Lond). 2008; 32 (3): 429-35. download pdf
Thioredoxin-Binding Protein-2-Like Inducible Membrane Protein Is a Novel Vitamin D3 and Peroxisome Proliferator-Activated Receptor (PPAR) Ligand Target Protein that Regulates PPAR Signaling. Shin-ichi Oka, Hiroshi Masutani, Wenrui Liu, Hiroyuki Horita, Dongmei Wang, Shinae Kizaka-Kondoh, and Junji Yodoi Endocrinology, Feb 2006; 147: 733 - 743. download pdf
Trans-10,cis-12 CLA increases adipocyte lipolysis and alters lipid droplet-associated proteins: role of mTOR and ERK signaling. Soonkyu Chung, Jonathan Mark Brown, Maria Boysen Sandberg, and Michael McIntosh J. Lipid Res., May 2005; 46: 885 - 895. download pdf
Viscoelastic properties of human mesenchymally-derived stem cells and primary osteoblasts, chondrocytes, and adipocytes. E. M. Darling, M. Topel, S. Zauscher, T. P. Vail and F. Guilak J Biomech. 2008; 41 (2): 454-64. download pdf
Zinc-alpha2-glycoprotein, a lipid mobilizing factor, is expressed in adipocytes and is up-regulated in mice with cancer cachexia. C. Bing, Y. Bao and J. Jenkins et al., Proc Natl Acad Sci U S A 101 (2004), pp. 2500-2505. download pdf
Regulation of adiponectin in adipocytes upon exposure to HIV-1. HIV Medicine. Sankalé J.-L., Tong, Q., Hadigan, C., Tan, G., Grinspoon, S., Kanki, P. and Hotamisligil, G. (2006), 7: 268-274. doi: 10.1111/j.1468-1293.2006.00372.x download pdf
miRNA and protein biomarkers in hypoxia for obesity studies (2014) Éric Mennesson, Isabelle Fixe, Alexandra Foucher, Flavien Carpentier, Nadia Normand download pdf
1,25-Dihydroxyvitamin D3 Modulation of Adipocyte Reactive Oxygen Species Production Xiaocun Sun and Michael B. Zemel Obesity, Aug 2007; 15: 1944 - 1953. download pdf
A novel selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor prevents human adipogenesis. I. J. Bujalska, L. L. Gathercole, J. W. Tomlinson, C. Darimont, J. Ermolieff, A. N. Fanjul, P. A. Rejto and P. M. Stewart J Endocrinol. 2008; 197 (2): 297-307. download pdf
Calcitriol and calcium regulate cytokine production and adipocyte-macrophage cross-talk. X. Sun and M. B. Zemel J Nutr Biochem. 2008; 19 (6): 392-9. download pdf
Endogenous ApoE Expression Modulates Adipocyte Triglyceride Content and Turnover Zhi Hua Huang, Catherine A. Reardon, and Theodore Mazzone Diabetes, Dec 2006; 55: 3394 - 3402. download pdf
Expression of the Human β3-Adrenergic Receptor Gene in SK-N-MC Cells Is Under the Control of a Distal Enhancer Vedrana S. Susulic, Lucille LaVallette, Emir Duzic, Liang Chen, David Shuey, Sotirios K. Karathanasis, and Kurt E. Steiner Endocrinology, May 2001; 142: 1935. download pdf
High efficiency lipid-based siRNA transfection of adipocytes in suspension G. Kilroy, D. H. Burk and Z. E. Floyd PLoS One. 2009; 4 (9): e6940. download pdf
HSV vector-mediated transduction and GDNF secretion from adipose cells. J. Fradette, D. Wolfe, W.F. Goins, S. Huang, R.M. Flanigan and J.C. Glorioso Gene Therapy, Jan 2005; 12: 48-58. download pdf
Identification of macrophage inhibitory cytokine-1 in adipose tissue and its secretion as an adipokine by human adipocytes Q. Ding, T. Mracek, P. Gonzalez-Muniesa, K. Kos, J. Wilding, P. Trayhurn and C. Bing Endocrinology. 2009; 150 (4): 1688-96. download pdf
In vitro investigations related to the hypothesis that Lipoatrophia semicircularis finds its origin in electro-stimulation. L. Verschaeve and A. Maes J Appl Toxicol. 2009; 29 (6): 478-82. download pdf
Inflammation may modulate IL-6 and C-reactive protein gene expression in the adipose tissue: the role of IL-6 cell membrane receptor Bruno Memoli, Alfredo Procino, Paolo Calabró, Pasquale Esposito, Giuseppe Grandaliano, Giovanni Pertosa, Marco Del Prete, Michele Andreucci, Saverio Di Lillo, Giuseppe Ferulano, Clemente Cillo, Silvia Savastano, Annamaria Colao, and Brunella Guida Am J Physiol Endocrinol Metab, Oct 2007; 293: E1030 - E1035. download pdf
Intronic Polymorphisms within TFAP2B Regulate Transcriptional Activity and Affect Adipocytokine Gene Expression in Differentiated Adipocytes. Shuichi Tsukada, Yasushi Tanaka, Hiroshi Maegawa, Atsunori Kashiwagi, Ryuzo Kawamori, and Shiro Maeda Mol. Endocrinol., May 2006; 20: 1104 - 1111. download pdf
Liver X Receptor (LXR) Regulation of the LXR Gene in Human Macrophages. Karl D. Whitney, Michael A. Watson, Bryan Goodwin, Cristin M. Galardi, Jodi M. Maglich, Joan G. Wilson, Timothy M. Willson, Jon L. Collins, and Steven A. Kliewer J. Biol. Chem., Nov 2001; 276: 43509 - 43515. download pdf
Natriuretic peptides enhance the production of adiponectin in human adipocytes and in patients with chronic heart failure O. Tsukamoto, M. Fujita, M. Kato, S. Yamazaki, Y. Asano, A. Ogai, H. Okazaki, M. Asai, Y. Nagamachi, N. Maeda, Y. Shintani, T. Minamino, M. Asakura, I. Kishimoto, T. Funahashi, H. Tomoike and M. Kitakaze J Am Coll Cardiol. 2009; 53 (22): 2070-7. download pdf
Nicotinic Acid Receptor Agonists Differentially Activate Downstream Effectors. Jeremy G. Richman, Martha Kanemitsu-Parks, Ibragim Gaidarov, Jill S. Cameron, Peter Griffin, Hong Zheng, Nuvia C. Guerra, Linda Cham, Dominique Maciejewski-Lenoir, Dominic P. Behan, Doug Boatman, Ruoping Chen, Philip Skinner, Pricilla Ornelas, M. Gerard Waters, Samuel D. Wright, Graeme Semple, and Daniel T. Connolly J. Biol. Chem., Jun 2007; 282: 18028 - 18036. download pdf
Octanoate Inhibits Triglyceride Synthesis in 3T3-L1 and Human Adipocytes. Wen Guo, Tianguang Lei, Tong Wang, Barbara E. Corkey, and Jianrong Han J. Nutr., Aug 2003; 133: 2512 - 2518. download pdf
PKC- Mediates Insulin Effects on Glucose Transport in Cultured Preadipocyte-Derived Human Adipocytes. Gautam Bandyopadhyay, Mini P. Sajan, Yoshinori Kanoh, Mary L. Standaert, Michael J. Quon, Rene Lea-Currie, Anindita Sen, and Robert V. Farese J. Clin. Endocrinol. Metab., Feb 2002; 87: 716 - 723. download pdf
PPAR regulates adipocyte cholesterol metabolism via oxidized LDL receptor 1. Patricia C. Chui, Hong-Ping Guan, Michael Lehrke, and Mitchell A. Lazar J. Clin. Invest., Aug 2005; 115: 2244 - 2256. download pdf
RhoA induces expression of inflammatory cytokine in adipocytes Y. Nakayama, R. Komuro, A. Yamamoto, Y. Miyata, M. Tanaka, M. Matsuda, A. Fukuhara and I. Shimomura Biochem Biophys Res Commun. 2009; 379 (2): 288-92. download pdf
Role of intracellular calcium in human adipocyte differentiation. HANG SHI, YUAN-DI HALVORSEN, PAMELA N. ELLIS, WILLIAM O. WILKISON, and MICHAEL B. ZEMEL Physiol Genomics, Aug 2000; 3: 75. download pdf
The adipose tissue triglyceride lipase ATGL/PNPLA2 is downregulated by insulin and TNF- in 3T3-L1 adipocytes and is a target for transactivation by PPAR. Ji Young Kim, Kristin Tillison, Jun-Ho Lee, David A. Rearick, and Cynthia M. Smas Am J Physiol Endocrinol Metab, Jul 2006; 291: E115 - E127. download pdf
The Low Density Lipoprotein Receptor-related Protein Contributes to Selective Uptake of High Density Lipoprotein Cholesteryl Esters by SW872 Liposarcoma Cells and Primary Human Adipocytes. Gerard Vassiliou, Fabienne Benoist, Paulina Lau, Gul Nihan Kavaslar, and Ruth McPherson J. Biol. Chem., Dec 2001; 276: 48823 - 48830. download pdf
The role of cyclic nucleotide phosphodiesterases in the regulation of adipocyte lipolysis. Peter B. Snyder, James M. Esselstyn, Kate Loughney, Sharon L. Wolda, and Vincent A. Florio J. Lipid Res., Mar 2005; 46: 494 - 503. download pdf
Thiazolidinediones and Rexinoids Induce Peroxisome Proliferator-Activated Receptor-Coactivator (PGC)-1 Gene Transcription: An Autoregulatory Loop Controls PGC-1 Expression in Adipocytes via Peroxisome Proliferator-Activated Receptor- Coactivation. Elayne Hondares, Ofelia Mora, Pilar Yubero, Marisa Rodriguez de la Concepción, Roser Iglesias, Marta Giralt, and Francesc Villarroya Endocrinology, Jun 2006; 147: 2829 - 2838. download pdf
Trans-10, Cis-12, But Not Cis-9, Trans-11, Conjugated Linoleic Acid Attenuates Lipogenesis in Primary Cultures of Stromal Vascular Cells from Human Adipose Tissue. J. M. Brown, Y. D. Halvorsen, Y. R. Lea-Currie, C. Geigerman, and M. McIntosh J. Nutr., Sep 2001; 131: 2316 - 2321. download pdf
Transcriptional regulation of the adipocyte fatty acid synthase gene by agouti: interaction with insulin. KATE J. CLAYCOMBE, YANXIN WANG, BRYNN H. JONES, SUYEON KIM, WILLIAM O. WILKISON, MICHAEL B. ZEMEL, JOSEPH CHUN, and NAIMA MOUSTAID-MOUSSA Physiol Genomics, Sep 2000; 3: 157. download pdf
Tumor Necrosis Factor- Stimulates Lipolysis in Differentiated Human Adipocytes Through Activation of Extracellular Signal-Related Kinase and Elevation of Intracellular cAMP. Hui H. Zhang, Melanie Halbleib, Faiyaz Ahmad, Vincent C. Manganiello, and Andrew S. Greenberg Diabetes, Oct 2002; 51: 2929. download pdf
Melanocortin receptor-mediated mobilization of intracellular free calcium in HEK293 cells. KATHLEEN G. MOUNTJOY, PHILIP L. KONG, JOHN A. TAYLOR, DERRIL H. WILLARD, and WILLIAM O. WILKISON Physiol Genomics, Feb 2001; 5: 11. download pdf
Molecular Identification of High and Low Affinity Receptors for Nicotinic Acid. Alan Wise, Steven M. Foord, Neil J. Fraser, Ashley A. Barnes, Nabil Elshourbagy, Michelle Eilert, Diane M. Ignar, Paul R. Murdock, Klaudia Steplewski, Andrew Green, Andrew J. Brown, Simon J. Dowell, Philip G. Szekeres, David G. Hassall, Fiona H. Marshall, Shelagh Wilson, and Nicholas B. Pike J. Biol. Chem., Mar 2003; 278: 9869 - 9874. download pdf
Recent Publications: PreadipocytesView
Targeting exosomes from preadipocytes inhibits preadipocyte to cancer stem cell signaling in early-stage breast cancer Ramkishore Gernapudi, Yuan Yao, Yongshu Zhang, Benjamin Wolfson, Sanchita Roy, Nadire Duru, Gabriel Eades, Peixin Yang, Qun Zhou
Breast Cancer Research & Treatment, March 2015
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Quantification of lipid droplets and associated proteins in cellular models of obesity via high-content/high-throughput microscopy and automated image analysis P. M. McDonough, R. M. Agustin, R. S. Ingermanson, P. A. Loy, B. M. Buehrer, J. B. Nicoll, N. L. Prigozhina, I. Mikic and J. H. Price Assay Drug Dev Technol. 2009; 7 (5): 440-60. download pdf
Thyroid hormone responsive Spot 14 increases during differentiation of human adipocytes and its expression is down-regulated in obese subjects F. J. Ortega, A. Vazquez-Martin, J. M. Moreno-Navarrete, J. Bassols, J. Rodriguez-Hermosa, J. Girones, W. Ricart, B. Peral, F. J. Tinahones, G. Fruhbeck, J. A. Menendez and J. M. Fernandez-Real Int J Obes (Lond). 2009; Epub ahead of print download pdf
Heterochromatin protein 1gamma epigenetically regulates cell differentiation and exhibits potential as a therapeutic target for various types of cancers M. Takanashi, K. Oikawa, K. Fujita, M. Kudo, M. Kinoshita and M. Kuroda Am J Pathol. 2009; 174 (1): 309-16. download pdf
Insulin sensitization of human preadipocytes through glucocorticoid hormone induction of forkhead transcription factors J. J. Tomlinson, A. Boudreau, D. Wu, H. Abdou Salem, A. Carrigan, A. Gagnon, A. J. Mears, A. Sorisky, E. Atlas and R. J. Hache Mol Endocrinol. 2010; 24 (1): 104-13. download pdf
IL-33, a recently identified interleukin-1 gene family member, is expressed in human adipocytes I. S. Wood, B. Wang and P. Trayhurn Biochem Biophys Res Commun. 2009; 384 (1): 105-9. download pdf
Inhibition of 11βHSD1 with the S-phenylethylaminothiazolone BVT116429 increases adiponectin concentrations and improves glucose homeostasis in diabetic KKAγ mice. M. Sundbom, C. Kaiser, E. Björkstrand, V. M. Castro, C. Larsson, G. Selén, C. S. Nyhem and S. R. James BMC Pharmacol. 2008; 8 3. download pdf
Role of Calcitriol and Cortisol on Human Adipocyte Proliferation and Oxidative and Inflammatory Stress: A Microarray Study. Xiaocun Sun, Kristin L. Morris, Michael B. Zemel Journal of Nutrigenetics and Nutrigenomics, 2008;1:30-48. download pdf
1,25-dihydroxyvitamin D3 inhibits uncoupling protein 2 expression in human adipocytes. Hang Shi, Anthony W. Norman, William H. Okamura, Anindita Sen, and Michael B. Zemel FASEB J, Sep 2002; 10.1096/fj.02-0255fje. download pdf
A Human Adenovirus Enhances Preadipocyte Differentiation. Sharada D. Vangipuram, Jonathan Sheele, Richard L. Atkinson, Thomas C. Holland, and Nikhil V. Dhurandhar Obes. Res., May 2004; 12: 770 - 777. download pdf
A Novel Method for Analysis of Nuclear Receptor Function at Natural Promoters: Peroxisome Proliferator-Activated Receptor Agonist Actions on aP2 Gene Expression Detected Using Branched DNA Messenger RNA Quantitation. Thomas P. Burris, Patricia D. Pelton, Lubing Zhou, Melville C. Osborne, Ellen Cryan, and Keith T. Demarest Mol. Endocrinol., Mar 1999; 13: 410. download pdf
Activation of Lipoprotein Lipase by Glucose-dependent Insulinotropic Polypeptide in Adipocytes: A ROLE FOR A PROTEIN KINASE B, LKB1, AND AMP-ACTIVATED PROTEIN KINASE CASCADE. Su-Jin Kim, Cuilan Nian, and Christopher H. S. McIntosh J. Biol. Chem., Mar 2007; 282: 8557 - 8567. download pdf
Agouti Expression in Human Adipose Tissue: Functional Consequences and Increased Expression in Type 2 Diabetes. Steven R. Smith, Barbara Gawronska-Kozak, Lenka Janderová, Taylor Nguyen, Angela Murrell, Jacqueline M. Stephens, and Randall L. Mynatt Diabetes, Dec 2003; 52: 2914. download pdf
Angiotensin II Regulates Adipocyte Apolipoprotein E Expression. Poornima Rao, Zhi Hua Huang, and Theodore Mazzone J. Clin. Endocrinol. Metab., Nov 2007; 92: 4366 - 4372. download pdf
Calcium and 1,25-Dihydroxyvitamin D3 Regulation of Adipokine Expression. Xiaocun Sun and Michael B. Zemel Obesity, Feb 2007; 15: 340 - 348. download pdf
Expression and secretion of inflammation-related adipokines by human adipocytes differentiated in culture: integrated response to TNF. Bohan Wang, John R. Jenkins, and Paul Trayhurn Am J Physiol Endocrinol Metab, Apr 2005; 288: E731 - E740. download pdf
Halofenate Is a Selective Peroxisome Proliferator-Activated Receptor Modulator With Antidiabetic Activity. Tamara Allen, Fang Zhang, Shonna A. Moodie, L. Edward Clemens, Aaron Smith, Francine Gregoire, Andrea Bell, George E.O. Muscat, and Thomas A. Gustafson Diabetes, Sep 2006; 55: 2523 - 2533. download pdf
Long-term treatment with interleukin-1β induces insulin resistance in murine and human adipocytes. C. Lagathu, L. Yvan-Charvet, J. P. Bastard, M. Maachi, A. Quignard-Boulangé, J. Capeau and M. Caron Diabetologia July 2006; 49:216-2173. download pdf
Modulation of Early Human Preadipocyte Differentiation by Glucocorticoids. Julianna J. Tomlinson, Adéle Boudreau, Dongmei Wu, Ella Atlas, and Robert J. G. Hachá Endocrinology, Nov 2006; 147: 5284 - 5293 download pdf
Orphan Nuclear Receptor NOR-1 Enhances 3',5'-Cyclic Adenosine 5'-Monophosphate-Dependent Uncoupling Protein-1 Gene Transcription. N. Kumar, D. Liu, H. Wang, J. Robidoux and S. Collins Mol Endocrinol. 2008; 22 (5): 1057-64. download pdf
Overexpression of Kruppel-Like Factor 7 Regulates Adipocytokine Gene Expressions in Human Adipocytes and Inhibits Glucose-Induced Insulin Secretion in Pancreatic β-Cell Line. Yoshihiro Kawamura, Yasushi Tanaka, Ryuzo Kawamori, and Shiro Maeda Mol. Endocrinol., Apr 2006; 20: 844 - 856. download pdf
PCR arrays identify metallothionein-3 as a highly hypoxia-inducible gene in human adipocytes. B. Wang, I. S. Wood and P. Trayhurn Biochem Biophys Res Commun. 2008; 368 (1): 88-93. download pdf
Pro-inflammatory delipidizing cytokines reduce adiponectin secretion from human adipocytes without affecting adiponectin oligomerization. Peter J Simons, Petra S van den Pangaart, Johannes M F G Aerts, and Louis Boon J. Endocrinol., Feb 2007; 192: 289 - 299. download pdf
Recombinant Human FIZZ3/Resistin Stimulates Lipolysis in Cultured Human Adipocytes, Mouse Adipose Explants, and Normal Mice. Tatiana Ort, Anibal A. Arjona, John R. MacDougall, Pam J. Nelson, Mark E. Rothenberg, Frank Wu, Andrew Eisen, and Yuan-Di C. Halvorsen Endocrinology, May 2005; 146: 2200 - 2209. download pdf
Regulation of lipin-1 gene expression by glucocorticoids during adipogenesis. P. Zhang, L. O'Loughlin, D. N. Brindley and K. Reue J Lipid Res. 2008; 49 (7): 1519-28. download pdf
Relationship between Human Adipose Tissue Agouti and Fatty Acid Synthase (FAS). Bingzhong Xue and Michael B. Zemel J. Nutr., Oct 2000; 130: 2478 - 2481. download pdf
The Differential Interactions of Peroxisome Proliferator-Activated Receptor Ligands with Tyr473 Is a Physical Basis for Their Unique Biological Activities. Monica Einstein, Taro E. Akiyama, Gino A. Castriota, Chuanlin F. Wang, Brian McKeever, Ralph T. Mosley, Joseph W. Becker, David E. Moller, Peter T. Meinke, Harold B. Wood, and Joel P. Berger Mol. Pharmacol., Jan 2008; 73: 62 - 74. download pdf
White Tea extract induces lipolytic activity and inhibits adipogenesis in human subcutaneous (pre)-adipocytes. J. Söhle, A. Knott, U. Holtzmann, R. Siegner, E. Grönniger, A. Schepky, S. Gallinat, H. Wenck, F. Stäb and M. Winnefeld Nutr Metab (Lond). 2009; 6 20. download pdf
Effects of androgens on adipocyte differentiation and adipose tissue explant metabolism in men and women. Blouin, K., Nadeau, M., Perreault, M., Veilleux, A., Drolet, R., Marceau, P., Mailloux, J., Luu-The, V. and Tchernof, A. (2010) Clinical Endocrinology, 72: 176-188. doi: 10.1111/j.1365-2265.2009.03645.x download pdf

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