Anti-Wrinkle Compound Screening

Our differentiation assay provides the tools to study the compounds that stimulate human adipocyte differentiation or lipogenesis. Compounds that increase lipid accumulation or trigger differentiation of fat cells may decrease the appearance of fine lines or wrinkles. Such compounds may be PPAR. agonists or a combination of thiazolidinediones and glucocorticoids that are potentially useful in the stimulation and maintenance of human fat cells.

This assay is designed to test compounds as potential PPAR. agonists. It is our experience that the PPAR. agonist used as the Positive Control sufficiently stimulates human adipocyte differentiation after 7 days of treatment. The protocol is designed so that the test compounds are also used in a 7-day treatment regimen. The end point assay is total triglyceride content of the cells 2 weeks after the initiation of differentiation.

Representative data set obtained for two concentrations of customer extracts using anti-wrinkling compound screening service; PC= positive control (PPAR-gamma agonist) VC= (vehicle control)

Ordering Information

Item#	Item Desc	U/M	Price
CA-13	Differentiation Assay: Total Triglyceride		Call

Prices for contract services vary depending on number of sample numbers, special conditions, compound solubility, etc. Minimum charges will apply. Please contact us for detailed information and a price quote on your project.

To learn more about our services, please contact our Services Team